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Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 276, Issue 3–4, pp 395–402 | Cite as

Vagal ascent and distribution of 125I-tetanus toxin after injection into the anterior wall of the stomach

  • B. Hensel
  • U. C. Seib
  • H. H. Wellhöner
Original Papers

Summary

  1. 1.

    125I-tetanus toxin has been injected in cats subperitoneally into the anterior wall of the stomach. The animals were dissected 32–36 h later.

     
  2. 2.

    The radioactivity in the vagus nerves was maximal near the stomach, passed through a minimum and increased again in the direction towards the CNS. In the minimum it was still five times higher than in other nerves.

     
  3. 3.

    The radioactivity in the pontine region containing the vagal nuclei was significantly elevated and 1.3 times that of the spinal cord at the Th 1 level.

     
  4. 4.

    In addition, the left pontine half was found to have a higher radioactivity than the right in three out of eight cats.

     
  5. 5.

    The results are explained as further evidence that tetanus toxin might ascend in nerve parts free of skeletomotor or fusimotor axons.

     

Key words

Tetanus Toxin Pharmacokinetics Neural Ascent Vagus Nerve 

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • B. Hensel
    • 1
  • U. C. Seib
    • 1
  • H. H. Wellhöner
    • 1
  1. 1.Pharmakologisches Institut der Justus-Liebig-Universität GießenGießenGermany

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