Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 276, Issue 3–4, pp 387–394 | Cite as

Local tetanus in cats: The influence of neuromuscular activity on spinal distribution of 125I labelled tetanus toxin

  • H. H. Wellhöner
  • U. C. Seib
  • B. Hensel
Original Papers

Summary

The “muscle pump” hypothesis of Ponomarew and Wright has been reexaminated with 125I labelled tetanus toxin in cats. The same amount of toxin was injected into either gastrocnemius muscle.

  1. 1.

    On direct stimulation of one gastrocnemius muscle, a higher amount of radioactivity was found on the stimulated side in the L6-S1 spinal cord half segments and their ventral roots.

     
  2. 2.

    If the same experiments were performed with the ventral roots L5-S2 ligated on both sides, no side differences in radioactivity were observed.

     
  3. 3.

    On stimulation of one sciatic nerve, an increased radioactivity was found on the stimulated side in the L6-S1 spinal cord half segments.

     
  4. 4.

    If the experiments were performed as in 3, but with the ventral roots L5-S2 ligated on both sides, no side difference in radioactivity was observed in the spinal cord.

     
  5. 5.

    On stimulation of the peripheral stump of one hamstring nerve, no side difference in radioactivity was observed.

     
  6. 6.

    On unilateral orthodromic stimulation of the dorsal roots in curarized animals, a higher radioactivity was found in the ipsilateral spinal cord segments L6-S1.

     
  7. 7.

    On unilateral antidromic stimulation of the peripheral stumps of the dorsal roots L6-S1, more radioactivity was found on the stimulated side in the L6-S1 spinal cord half segments.

     
  8. 8.

    On bilateral antidromic stimulation of the dorsal roots L6-S1 and unilateral local anesthesia of the sciatic nerve in the hollow of the knee, the radioactivity was found to be lower in the spinal cord half segments of the anesthetized side.

     
  9. 9.

    The results provide evidence that in the absence of any muscular activity neural activity per se advances the ascent of tetanus toxin through the ventral roots into the spinal cord.

     

Key words

Tetanus Toxin Local Tetanus Pharmacokinetics Neural Movement Muscle Pump 

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References

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  9. Wellhöner, H. H., Hensel, B., Seib, U. C.: Local tetanus in cats: Neuropharmacolkinetics of 125I-tetanus toxin. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 375–386 (1973).Google Scholar
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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • H. H. Wellhöner
    • 1
  • U. C. Seib
    • 1
  • B. Hensel
    • 1
  1. 1.Pharmakologisches Institut der Justus Liebig-Universität GießenGießenGermany

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