Skip to main content
Log in

A note on the specific fixation, specific deactivation and non-specific inactivation of bacterial toxins by gangliosides

  • Original Papers
  • Published:
Naunyn-Schmiedeberg's Archives of Pharmacology Aims and scope Submit manuscript

Summary

The fixation of tetanus toxin and the deactivation of cholera toxin by gangliosides are toxin-specific and ganglioside-specific, and not prevented by protective colloid, whereas the inactivation of a number of toxins by gangliosides which is prevented by protective colloid is a non-specific phenomenon.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Coleman, G. E.: Action of leukocytes and of brain tissue on toxin of B. botulinus. J. infect. Dis. 34, 614–620 (1924).

    Google Scholar 

  • Doery, H. M., North, E. A.: The interaction of staphylococcal toxin and ganglioside. 1. Inactivation of the lethal effect of staphylococcal toxin in mice. Aust. J. exp. Biol. med. Sci. 39, 333–344 (1961).

    Google Scholar 

  • Mellanby, J., Mellanby, H., Pope, D., van Heyningen, W. E.: Ganglioside as a prophylactic agent in experimental tetanus in mice. J. gen. Microbiol. 54, 161–168 (1968).

    Google Scholar 

  • Mellanby, J., Thompson, P. A., Hampden, N.: On the similarity of tetanus and botulinum toxins. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 303–310 (1973).

    Google Scholar 

  • North, E. A., Doery, H. M.: Inactivation of staphylococcal, tetanus and diphtheria toxins by ganglioside. Brit. J. exp. Path. 42, 23–29 (1961).

    Google Scholar 

  • Raskova, H., Masek, K.: Pharmacology of bacterial toxin proteins. In: Microbial toxins, Vol. 1, pp. 329–354. New York-London: Academic Press Inc. 1970.

    Google Scholar 

  • Simpson, L. L., Rapport, M. M.: Ganglioside inactivation of botulinum toxin. J. Neurochem. 18, 1341–1343 (1971).

    Google Scholar 

  • Van Heyningen, W. E.: The fixation of tetanus toxin by nervous tissue. J. gen. Microbiol. 20, 291–300 (1959a).

    Google Scholar 

  • Van Heyningen, W. E.: Chemical assay of the tetanus toxin receptor in nervous tissue. J. gen. Microbiol. 20, 301–309 (1959b).

    Google Scholar 

  • Van Heyningen, W. E.: Tentative identification of the tetanus toxin receptor in nervous tissue. J. gen. Microbiol. 20, 310–320 (1959c).

    Google Scholar 

  • Van Heyningen, W. E.: The relation between the fixation and inactivation of tetanus toxin by ganglioside. Brit. J. exp. Path. 42, 397–398 (1961).

    Google Scholar 

  • Van Heyningen, W. W.: The fixation of tetanus toxin, strychnine, serotonin and other substances by ganglioside. J. gen. Microbiol. 31, 375–387 (1963).

    Google Scholar 

  • Van Heyningen, W. E.: On the similarity of tetanus and cholera toxins. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 289–295 (1973).

    Google Scholar 

  • Van Heyningen, W. E., Carpenter, C. C. J., Pierce., N. F., Greenough III, W. B.: Deactivation of cholera toxin by ganglioside. J. infect. Dis. 124, 415–418 (1971).

    Google Scholar 

  • Van Heyningen, W. E., Mellanby, J.: The effect of cerebroside and other lipids on the fixation of tetanus toxin by gangliosides. J. gen. Microbiol. 52, 447–454 (1968).

    Google Scholar 

  • Wassermann, A., Takaki, T.: Über tetanusantitoxische Eigenschaften des normalen Centralnervensystems. Berl. klin. Wschr. 35, 5–6 (1898).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

van Heyningen, W.E., Mellanby, J. A note on the specific fixation, specific deactivation and non-specific inactivation of bacterial toxins by gangliosides. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 297–302 (1973). https://doi.org/10.1007/BF00499883

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00499883

Key words

Navigation