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Effect of a “therapeutic” concentration of digitoxigenine on myocardial potassium and sodium content in Ca-poor media

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Summary

The effect of 3·10−7 g/ml digitoxigenine on cellular K and Na concentrations, [K]i and [Na]i, water content, extracellular space, and contractile force was investigated in isolated electrically stimulated left guinea-pig auricles at reduced extracellular Ca concentration (0.45 mM). Digitoxigenine, which increased contractile force without producing arrhythmias or contractures, decreased [K]i and enhanced [Na]i. Water content and extracellular space remained unchanged. It is concluded that digitoxigenine can decrease myocardial [K]i and increase [Na]i even in “therapeutic” concentrations, provided that the experiments are performed in Ca-poor media.

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References

  • Glitsch, H. G.: Über das Membranpotential des Meerschweinchenvorhofes nach Hypothermie. Pflügers Arch. 307, 29–46 (1969).

    Google Scholar 

  • —: Über einige Eigenschaften des aktiven Na+-Transports am Myokard. Dtsch. med. Wschr. 95, 963–970 (1970).

    Google Scholar 

  • Klaus, W.: Neuere Aspekte über den Wirkungsmechanismus der Herzglykoside. Z. naturwiss.-med. Grundlagenforsch. 2, 43–117 (1964).

    Google Scholar 

  • Lahrtz, H. G., Lüllmann, H., van Zwieten, P. A.: Calcium transport in isolated guinea-pig atria during metabolic inhibition. Biochim. biophys. Acta (Amst.) 135, 701–709 (1967).

    Google Scholar 

  • Lee, K. S., Klaus, W.: The subcellular basis for the mechanism of inotropic action of cardiac glycosides. Pharmacol. Rev. 23, 193–261 (1971).

    Google Scholar 

  • Page, E., Goerke, R. J., Storm, S. R.: Cat heart muscle in vitro. IV. Inhibition of transport in quiescent muscles. J. gen. Physiol. 47, 531–543 (1964).

    Google Scholar 

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität Mainz, Mainz, Germany

    H. Scholz

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  1. H. Scholz
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Supported by the Deutsche Forschungsgemeinschaft.

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Scholz, H. Effect of a “therapeutic” concentration of digitoxigenine on myocardial potassium and sodium content in Ca-poor media. Naunyn-Schmiedeberg's Arch. Pharmacol. 273, 434–437 (1972). https://doi.org/10.1007/BF00499679

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  • DOI: https://doi.org/10.1007/BF00499679

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