Summary
Lead augments potassium release from perfused rat livers to a much lower extent than from red cells. In contrast mercurials increase cationic permeability of red cells and liver cells to a similar extent. Data from liver perfusions were compared with earlier findings on red cells reported by Passow.
This is a preview of subscription content, log in via an institution to check access.
References
Frimmer, M., Gries, J., Hegner, D., Schnorr, B.: Studies of the mechanisms of the action of phalloidin. Release of enzymes and potassium. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 258, 197–214 (1967).
—, Kreh, W.: Unexpected temperature dependence of potassium release from the isolated perfused rat liver. Naunyn-Schmiedebergs Arch. Pharmak. 270, 313 to 315 (1971).
Lutz, F., Kreh, W., Frimmer, M.: The influence of SH-reactive diuretics on the movement of cations on rat liver membranes. Naunyn-Schmiedebergs Arch. Pharmak. 270, R 92 (1971).
Passow, W.: The red blood cell: Penetration, distribution and toxic actions of heavy metals. In: Effects of metals on cells, subcellular elements, and macromolecules, pp. 291–344. J. Maniloff, J. R. Coleman, M. W. Miller, eds. Springfield, Ill.: Ch. C. Thomas 1971.
Sutherland, R. M., Rothstein, A., Weed, R. L.: Erythrocyte membrane sulfhydryl groups and cation permeability. J. cell. Physiol. 69, 185–198 (1967).
Author information
Authors and Affiliations
Additional information
This work is supported by the Deutsche Forschungsgemeinschaft.
Rights and permissions
About this article
Cite this article
Frimmer, M. Action of lead on the cationic balance in the perfused rat liver. Naunyn-Schmiedeberg's Arch. Pharmacol. 273, 427–429 (1972). https://doi.org/10.1007/BF00499677
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00499677