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Effect of halothane on the hepatic drug metabolizing system

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Summary

Pretreatment with 2 Vol.-% halothane in oxygen for 1 h once daily on 5 days significantly decreased the hexobarbital sleeping time by about 49%. The activity of the NADPH-cytochrome c reductase was increased by 33%, whereas the amount of cytochrome P450 was not altered.

A prolongation of the daily halothane exposure to 2 h increased the activity of the NADPH-cytochrome c reductase by about 60%.

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Authors and Affiliations

  1. Abteilung für Anaesthesiologie der Universität Würzburg, Würzburg, Germany

    I. Rietbrock, G. Lazarus & A. Otterbein

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  1. I. Rietbrock
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  2. G. Lazarus
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  3. A. Otterbein
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Rietbrock, I., Lazarus, G. & Otterbein, A. Effect of halothane on the hepatic drug metabolizing system. Naunyn-Schmiedeberg's Arch. Pharmacol. 273, 422–426 (1972). https://doi.org/10.1007/BF00499676

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  • DOI: https://doi.org/10.1007/BF00499676

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