Summary
-
1.
Anaphylatoxin lowers the histamine content in the guinea pig lung. This decrease can be demonstrated only immediately after the shock. 1 h later the decrease is no longer significant and normal values are being restored within 1 day.
-
2.
The lung histamine content cannot be depressed to a larger extent and/or for a longer period of time by repeated anaphylatoxin injections neither during tachyphylaxis (every second hour) nor when tachyphylaxis is diminished (every day) nor when it has completely disappeared (every second day).
-
3.
Anaphylatoxin pretreatment (3 times every second hour) does not protect from the lethal effect of anaphylactic shock provoked either by a large or by a small dose of antigen. The plasma histamine level is only slightly decreased and a similar effect can be achieved by pretreatment with rat serum. Pretreatment with Ringer solution caused an increase in the plasma histamine level during anaphylactic shock. It seems unlikely that an anaphylactic shock can be diminished by a preceding depletion of the histamine stores with the aid of anaphylatoxin.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bernauer, W., Giertz, H., Hahn, F., Schmutzler, W., Seseke, G., Sievers, B. U.: Zum Mechanismus der Histaminaseaktivierung im anaphylaktischen Schock. Naturwissenschaften 51, 412–413 (1964).
Frick, O. L., Halpern, B. N., Liacopoulos, P.: The mechanism of protection from anaphylactic shock in the guinea-pig by pretreatment with anaphylatoxin. J. Physiol. (Lond.) 163, 191–199 (1962).
Friedberg, K. D., Bauer, U.: Anaphylaktischer Schock nach passiver Sensibilisierung am anaphylatoxinvorbehandelten Meerschweinchen. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 250, 171–172 (1965).
—, Engelhardt, G., Meineke, F.: Über die Tachyphylaxie der Anaphylatoxin-reaktion und ihre Bedeutung für die Anaphylaxie. Int. Arch. Allergy 22, 166–169 (1963).
———: Untersuchungen über die Anaphylatoxin-Tachyphylaxie und ihre Bedeutung für den Ablauf echter anaphylaktischer Reaktionen. Int. Arch. Allergy 25, 154–181 (1964).
Friedberg, K. D., Garbe, G., Grützmacher, J.: Untersuchungen über die antianaphylaktische Wirkung des Chlorophyllins. Naunyn-Schmiedebergs Arch. Pharmak. 265, 287–300 (1969).
—, Poppe, I.: Über die Histaminfreisetzung aus der Meerschweinchenlunge durch Anaphylatoxin. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 257, 19 (1967).
Garbe, G., Friedberg, K. D.: Properties of the histamine stores affected in the anaphylactic and anaphylatoxin shock of the guinea pig. II. Effect of pretreatment with antigen. Naunyn-Schmiedeberg's Arch. Pharmacol. 273, 414–421 (1972).
Giertz, H., Hahn, F.: Die inverse Anaphylaxie vom Standpunkt der Histamintheorie der Anaphylaxie. Int. Arch. Allergy 6, 23–44 (1955).
——: Makromolekulare Histaminliberatoren. In: M. Rocha e Silva: Histamine and Antihistaminics. Handbook of exp. Pharmacol., Vol. XVIII/1, pp. 543–544. Berlin-Heidelberg-New York: Springer 1966.
Hahn, F.: Anaphylatoxin and anaphylaxis. Exerpta Medica International Congress Series Nr. 162, pp. 145–159. Allergology, Proceedings Sixth Congress of the International Association of Allergology. Montreal Nov. 5–11, 1967.
— Ebner, C., Giertz, H.: Anaphylatoxin tachyphylaxis and anaphylaxis. Int. Arch. Allergy 35, 434–444 (1969).
— Maack, R., Müller, G., Mitze, R., Ebner, C.: Anaphylatoxin tachyphylaxis and anaphylactic histamine release. Int. Arch. Allergy 37, 596–606 (1970).
Halpern, B. N., Liacopoulos, P., Briot, M.: Mecanism de protection du cobaye contre le choc anaphylactique mortel par l'anaphylatoxin. Acta allerg. (Kbh.) 10, 9–14 (1956).
Mongar, J. L., Schild, H. O.: Quantitative measurement of the histamine-releasing activity of a series of monoalkylamines using minced guinea-pig lung. Brit. J. Pharmacol. 8, 103–109 (1953).
Mota, J.: The mechanism of action of anaphylatoxin. Its effect on guinea pig mast cells. Immunology 2, 403–413 (1959).
Shore, P. A., Burkhalter, A., Cohn, V. H.: A method for the fluorometric assay of histamine in tissues. J. Pharmacol. exp. Ther. 127, 182–186 (1959).
Spector, W. S.: Handbook of biological data, p. 190. Philadelphia-London: W. B. Saunders Comp. 1956.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Garbe, G., Friedberg, K.D. Properties of the histamine stores affected in the anaphylactic and anaphylatoxin shock of the guinea pig. Naunyn-Schmiedeberg's Arch. Pharmacol. 273, 401–413 (1972). https://doi.org/10.1007/BF00499674
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00499674