Summary
Hydantoin reduced the incidence of urethane induced lung adenomas in SWR mice. This tumor protective effect might be attributed to the modifying effect of the drug on the immunological system of the treated mice.
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References
Burnet, F. M.: Immunological factors in the process of carcinogenesis. Brit. med. Bull. 20, 154 (1964)
Easton, J. D.: Potential hazards of hydantoin use. Ann. intern. Med., 77, 998 (1972)
Grob, P. J., Herold, G. E.: Immunological abnormalities and hydantoins. Brit. med. J. 1972 II 561
Sorrell, T. C., Forbes, I. J., Burness, F. R., Rischbieth, R. H. C.: Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin). Lancet 1971 II, 1233
Trainin, N., Linker-Israeli, M., Small, M., Boiato-Chen, L.: Enhancement of lung adenoma formation by neonatal thymectomy in mice treated with 7,12-Dimethylbenz (a) anthracene or urethane. Int. J. Cancer 2, 326 (1967)
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Levo, Y. The protective effect of hydantoin treatment on carcinogenesis. Naunyn-Schmiedeberg's Arch. Pharmacol. 285, 29–30 (1974). https://doi.org/10.1007/BF00499526
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DOI: https://doi.org/10.1007/BF00499526