Biochemical Genetics

, Volume 22, Issue 9–10, pp 853–870 | Cite as

Heterogeneity of Es-1 esterases in the rabbit (Oryctolagus cuniculus)

  • H. Bellen
  • A. Van de Weghe
  • Y. Bouquet
  • L. F. M. Van Zutphen
Article

Abstract

Analysis of the Es-1 system in the rabbit with polyacrylamide gel electrophoresis (PAGE) revealed a high degree of individual variation. In the liver the number of esterase bands found in the Es-1 region of the gels ranged from 2 to 16. The results indicate that one locus with three alleles is responsible for all of the esterase bands in the Es-1 region. The most plausible explanation for the observed heterogeneity is that each of the alleles codes for a protein (MW 65,000±2000) that is changed by posttranslational modifications, thus giving rise to two to five monomeric enzymes with esterase activity. Polymerization of these monomers then results in 1–11 dimers. Based on similarities with mouse Es-9, chromosomal homology between rabbit Es-1 and mouse Es-9 is proposed.

Key words

esterase genetics rabbit 

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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • H. Bellen
    • 1
  • A. Van de Weghe
    • 1
  • Y. Bouquet
    • 1
  • L. F. M. Van Zutphen
    • 2
  1. 1.Department of Animal Genetics and Bloodgroups, Faculty of Veterinary MedicineState University of GhentGhentBelgium
  2. 2.Department of Laboratory Animal Science, Faculty of Veterinary MedicineUniversity of UtrechtUtrechtThe Netherlands

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