Summary
Haemodynamic variables were compared in control dogs, dogs with local tetanus toxicity and dogs with generalised tetanus toxicity. The results showed an increase in the inotropic and chronotropic activation of the heart in both groups of tetanus dogs, but there was no significant change in the mean systemic blood pressure and the common carotid occlusion reflex was unchanged.
Spontaneous fluctuations in the systemic blood pressure were observed in some dogs with tetanus, and occurred more often in those with generalised tetanus. The modification of these fluctuations by beta-adrenergic blockade and diazepam, suggest that they are of autonomic neural origin.
It is suggested that these changes in the cardiovascular system are the results of neurophysiological and biochemical changes in the sympathetic nervous system, which have been reported to occur in tetanus.
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References
Bonnevaux, S. C. De., Altares, M. C. Diez, Carrillo, L.: Autonomic response to pentamethylenetetrazol following trimetadione and benzodiazepines administration. Arch. int. Pharmacodyn. 173, 34–43 (1968)
Branthwaite, M. A., Bradley, R. D.: Measurement of cardiac output by thermal dilution in man. J. appl. Physiol. 24, 434–438 (1968)
Brooks, V. B., Curtis, D. R., Eccles, J. C.: The action of tetanus toxin on the inhibition of motoneurones. J. Physiol. (Lond.) 135, 655–672 (1957)
Busila, V. T., Dragomirescu, M., Alexandrescu, T., Martincu, V., Cucuruz, L., Rocsin, M., Lupu, D., Novac, E., Dragomirescu, L.: Metabolic changes in experimentally induced tetanus. Scand. J. infect. Dis. 3, 45–49 (1971)
Corbett, J. L., Harris, P. J.: Studies on the sympathetic nervous system in tetanus. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 447–460 (1973)
Corbett, J. L., Kerr, J. H., Prys-Roberts, C., Crampton Smith, A., Spalding, J. M. K.: Cardiovascular disturbances in severe tetanus due to overactivity of the sympathetic nervous system. Anaesthesia 24, 198–212 (1969)
Ganz, W., Swan, H. J. C.: Measurement of blood flow by thermodilution. Amer. J. Cardiol. 29, 241–246 (1972)
Habermann, E., Wellhöner, H. H.: Advances in tetanus research. Klin. Wschr. 52, 255–265 (1974)
Kanarek, D. J., Kaufman, B., Zwi, S.: Severe sympathetic hyperactivity associated with tetanus. Arch. intern. Med. 132, 602–604 (1973)
Kerr, J. H., Corbett, J. L., Prys-Roberts, C., Crampton Smith, A., Spalding, J. M. K.: Involvement of the sympathetic nervous system in tetanus. Lancet 1968 II, 236–241
Khalil, H. H., Richardson, T. Q., Guyton, A. C.: Measurement of cardiac output by thermal dilution and direct Fick methods in dogs. J. appl. Physiol. 21, 1131–1135 (1966)
Kryzhanovskii, G. N., Kassil, G. N., Grafova, V. N., Pukhova, G. S.: State of catecholamine metabolism in tetanus. Bull. exp. Biol. Med. 72, 25–28 (1971)
Marley, E., Stephenson, J. D.: Central actions of catecholamines. In: Handbook of Experimental Pharmacology, vol. XXXIII (H. Blaschko and E. Muscholl, eds.), pp. 461–537. Berlin-Heidelberg-New York: Springer 1972
Mikhailov, V. V., Chesknokova, N. P.: Changes in tissue concentrations of catecholamines in experimental tetanus. Bull. exp. Biol. Med. 71, 20–24 (1971)
Paar, G. H., Wellhöner, H. H.: The action of tetanus toxin on preganglionic sympathetic reflex discharges. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 437–445 (1973)
Paar, G. H., Wiegarg, H. J., Wellhöner, H. H.: The influence of tetanus toxin on sympathetic reflex discharges in renal nerves. Naunyn-Schmiedeberg's Arch. Pharmacol. 281, 383–390 (1974)
Pinakatt, T., Richardson, A. W.: Distribution of cardiac output in dogs. Amer. J. Physiol. 213, 905 (1967)
Reddy, I. P., Vaishnava, H. P., Dave, M. L., Sanyal, R. K.: Sympathomimetic action of tetanus toxin. J. Pharm. Pharmacol. 22, 464 (1970)
Sato, A., Schmidt: Somato sympathetic reflexes; afferent fibres, central pathways, discharge characteristics. Physiol. Rev. 53, 916–947 (1973)
Sigg, E. B., Sigg, T. D.: Hypothalamic stimulation of preganglionic autonomic activity and its modification by chlorpromazine, diazepam and pentobarbital. Int. J. Neuropharmacol. 8, 567–572 (1969)
Sofola, O. A., Odusote, K. A.: Sympathetic cardiovascular effects of experimental strychnine poisoning in dogs. J. Pharmacol. exp. Ther. 196, 29–34 (1976)
Tempero, K. F.: The use of diazepam in the treatment of tetanus. Amer. J. med. Sci. 266, 4 (1973)
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Odusote, K.A., Sofola, O.A. Haemodynamic changes during experimental tetanus toxicity in dogs. Naunyn-Schmiedeberg's Arch. Pharmacol. 295, 159–164 (1976). https://doi.org/10.1007/BF00499449
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DOI: https://doi.org/10.1007/BF00499449