Summary
Electrodermal responses (EDR) of the sympathetic-cholinergic sudomotor system were elicited in anaesthetized cats. Responses were evoked centrally from hypothalamic, medullary and spinal loci, by stimulation of the pre- and postganglionic peripheral nerves, and reflexly following stimulation of an afferent nerve. The response was found to be dependent upon innervation of both the median and ulnar nerves (approximately 40 and 60% respectively). Both the centrally and peripherally evoked responses were frequency-dependent when a maximal current was used. The EDR evoked peripherally or from the cervical cord reached its maximal amplitude at 10–16 Hz whereas the EDR evoked from the hypothalamus and medulla did not reach its maximal amplitude until 48–64 Hz. These responses are relatively independent of blood flow in that complete occlusion of the peripheral blood supply did not greatly alter the amplitude of centrally evoked responses. The results suggest that this sympathetic-cholinergic system may be a useful model system with which to study the actions of various adrenergic agents on the reactivity of central structures which regulate sympathetic nervous activity.
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Celesia, G. G., Wang, G. H.: Sudomotor activity induced by single shock stimulation of the hypothalamus in anaesthetized cats. Arch. ital. Biol. 102, 599–607 (1964)
Davison, M. A., Koss, M. C.: Brainstem loci for activation of electrodermal response in the cat. Amer. J. Physiol. 229, 930–934 (1975)
Davison, M. A., Koss, M. C.: The action of chlorpromazine on the electrodermal response in the cat. Neuropharmacology 15, 197–201 (1976)
Fowles, D. C., Venables, P. H.: The effects of epidermal hydration and sodium reabsorption on palmar skin potential. Psychol. Bull. 73, 363–378 (1970)
Karplus, J. P., Kreidl, A.: Gehirn und Sympathicus. II. Ein Sympathicuszentrum im Zwischenhirn. Pflügers Arch. ges. Physiol. 135, 401–417 (1910)
Koss, M. C., Davison, M. A.: The electrodermal response as a model for central sympathetic reactivity: the action of clonidine. Europ. J. Pharmacol. 37, 71–78 (1976)
Lang, A. H.: Skin D.C. potentials and the endosomatic galvanic skin reaction in the cat. Acta physiol. scand. 69, 230–241 (1967)
Lang, A. H.: On the physiological significance of the amplitude of the endosomatic galvanic skin reaction (GSR) in the cat. Acta physiol. scand. 73, 151–160 (1968)
Langley, J. N.: On the course and connections of the secretory fibers supplying the sweat glands of the feet of the cat. J. Physiol. (Lond.) 12, 347–374 (1891)
Langley, J. N.: Further observations on the secretory and vasomotor fibers of the foot of the cat, with notes on other sympathetic nerve fibres. J. Physiol. (Lond.) 17, 296–314 (1894/95)
Morimoto, T., Imai, Y., Watari, H.: Skin potential response and sweat output of the cat footpad. Jap. J. Physiol. 24, 205–215 (1974)
Ott, I., Wood Field, G. B. W.: Sweat centres: The effect of muscarin and atropin on them. J. Physiol. (Lond.) 1, 193–195 (1878)
Patton, H. D.: Secretory innervation of the cat's footpad. J. Neurophysiol. 11, 211–227 (1948)
Patton, H. D.: Effect of autonomic blocking agents on sweat secretion in cat. Proc. Soc. exp. Biol. (N.Y.) 70, 412–414 (1949)
Richter, C. P., Whelan, F.: Sweat glands responses to sympathetic stimulation studied by the galvanic skin reflex method. J. Neurophysiol. 6, 191–194 (1943)
Shaver, B. A., Brusilow, S. W., Cooke, R. E.: Origin of the galvanic skin response. Proc. Soc. exp. Biol. (N.Y.) 110, 559–564 (1962)
Wang, G. H.: The galvanic skin reflex. A review of old and recent works from a physiologic point of view. Amer. J. phys. Med. 36, 295–320 (1957)
Wang, G. H.: The galvanic skin reflex. A review of old and recent works from a physiologic point of view. Part II. Amer. J. phys. Med. 37, 35–57 (1958)
Wang, G. H.: The neural control of sweating. Madison: University of Wisconsin Press 1964
Wang, G. H., Lu, T. W.: On the intensity of the galvanic skin response induced by stimulation of post-ganglionic sympathetic nerve fibers with single induction shocks. Chin. J. Physiol. 4, 393–399 (1930)
Wang, G. H., Richter, C. P.: Action currents from the pad of the cat's foot produced by stimulation of the tuber cinereum. Chin. J. Physiol. 2, 279–284 (1928)
Wang, S. C., Mazzella, H., Heymans, C.: Hemodynamic studies on the carotid sinus pressoreceptive reflex: effects of occluding efferent branches of carotid bifurcation upon the sinus pressor responses. Arch. int. Pharmacodyn. 90, 1–17 (1952)
Wilcott, R. C.: A comparative study of the skin potential, skin resistance and sweating of the cat's footpad. Psychophysiology (Baltimore) 2, 62–71 (1965)
Yamazaki, K., Okuda, K., Tajimi, T., Niimi, Y.: Skin potential activity in rats, cats, and primates (including man): a phylogenetic point of view. J. comp. physiol. Psychol. 89, 364–370 (1975)
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This work was supported by USPHS grant No. MH25792 and a grant from the Pharmaceutical Manufacturers Association Foundation
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Koss, M.C., Davison, M.A. Characteristics of the electrodermal response. Naunyn-Schmiedeberg's Arch. Pharmacol. 295, 153–158 (1976). https://doi.org/10.1007/BF00499448
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DOI: https://doi.org/10.1007/BF00499448