Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 281, Issue 4, pp 437–441 | Cite as

Reduction in ventricular arrhythmias following acute coronary artery ligation in the dog after the administration of creatine phosphate

  • R. J. Marshall
  • J. R. Parratt
Short Communication

Summary

The infusion of creatine phosphate into the left ventricle of dogs markedly reduced the number of ventricular ectopic beats which normally result from acute coronary ligation. This dose of creatine phosphate (100 mg/kg) had no significant effect on resting haemodynamics or on myocardial metabolism.

Key words

Creatine Phosphate Acute Myocardial Infarction Arrhythmias Antiarrhythmic Activity 

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References

  1. Fisher, W., Heimbach, D., Ledingham, I. McA., Marshall, R. J., Parratt, J. R.: Blood flow and oxygen extraction in ischaemic and normal regions of the myocardium following acute coronary artery ligation. J. Physiol. (Lond.) 230, 15–17P (1973)Google Scholar
  2. Heald, P. J.: Phosphoprotein metabolism and ion transport in nervous tissue: a suggested connexion. Nature (Lond.) 193, 451–454 (1962)Google Scholar
  3. Marshall, R. J., Parratt, J. R.: The effect of acute anoxia on isolated cardiac muscle. J. Pharm. Pharmacol. (in press) (1974)Google Scholar
  4. Marshall, R. J., Parratt, J. R., Ledingham, I. McA.: Changes in blood flow and oxygen consumption in normal and ischaemic regions of the myocardium following acute coronary artery ligation. Cardiovasc. Res. 8, (in press) (1974)Google Scholar
  5. Parratt, J. R., Ledingham, I. McA., McArdle, C. S.: Effect of a coronary vasodilator drug (carbochromen) on blood flow and oxygen extraction in acute myocardial infarction. Cardiovasc. Res. 7, 401–407 (1973)Google Scholar
  6. Regan, T. J., Harman, M. A., Lehan, P. H., Burke, W. M., Oldewurtel, H. A.: Ventricular arrhythmias and K+ transfer during myocardial ischaemia and intervention with procaine amide, insulin or glucose solution. J. clin. Invest. 46, 1657–1668 (1967)Google Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • R. J. Marshall
    • 1
    • 2
  • J. R. Parratt
    • 1
    • 2
  1. 1.Department of Physiology and PharmacologyRoyal College University of StrathclydeGlasgowScotland
  2. 2.Department of SurgeryWestern InfirmaryGlasgowScotland

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