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The effect of dilazep on blood flow and oxygen handling in the early stages of canine myocardial infarction

Simultaneous comparison with changes in the normal myocardium

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Summary

The effects of dilazep, a drug which potentiates the actions of adenosine, were examined in a canine preparation that enabled simultaneous measurements to be made of blood flow both in ischaemic areas, and in essentially normal areas, of the canine myocardium. In doses which caused marked and sustained increases in blood flow to the normal myocardium, dilazep did not change either blood flow in the developing infarct or the trans-ventricular perfusion pressure (diastolic peripheral coronary pressure minus left ventricular end-diastolic pressure). Despite the lack of effect on infarct blood flow, the oxygen tension of the blood draining the infarcting area was markedly elevated. It is concluded that dilazep may open up blood vessels in an acutely ischaemic area which do not take part in tissue exchange, and may therefore decrease the efficiency of the myocardial circulation.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Royal College, University of Strathclyde, Glasgow, UK

    R. J. Marshall & J. R. Parratt

  2. Department of Surgery, Western Infirmary University of Glasgow, Glasgow, UK

    R. J. Marshall & J. R. Parratt

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  1. R. J. Marshall
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  2. J. R. Parratt
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Marshall, R.J., Parratt, J.R. The effect of dilazep on blood flow and oxygen handling in the early stages of canine myocardial infarction. Naunyn-Schmiedeberg's Arch. Pharmacol. 281, 427–436 (1974). https://doi.org/10.1007/BF00499437

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  • DOI: https://doi.org/10.1007/BF00499437

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