Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 281, Issue 4, pp 327–340 | Cite as

Amphetamine and thermoregulation: Studies in the unrestrained and curarized rat

  • Alexander A. Borbély
  • Isabel R. Baumann
  • Peter G. Waser
Article

Summary

We investigated the effect of (+)-amphetamine on body temperature in the unrestrained and curarized rat. In the unrestrained animal kept at an ambient temperature of 30°C amphetamine had a dose-dependent hyperthermic action, whereas in animals kept at 7°C it decreased body temperature. An increase in body temperature was evident also in the curarized rat; after spinal cord transection at the level of C1; and in the pithed rat. Pretreatment with the alpha-adrenergic blocking agent azapetine attenuated amphetamine-hyperthermia in the curarized rat, but enhanced the hyperthermic response in the unrestrained rat. Pretreatment with the beta-adrenergic blocking agent propranolol abolished amphetamine-hyperthermia in the curarized rat, but did not affect the response in the unrestrained animal. In the hypophysectomized animal amphetamine had a hypothermic effect even at high ambient temperatures. It is concluded that the action of amphetamine on peripheral beta-receptors has a hyperthermic effect, but that additional mechanisms are involved in the thermal response of the freely moving animal.

Key words

Amphetamine Body Temperature Adrenergic Receptor Azapetine Propranolol Hypophysectomy 

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Alexander A. Borbély
    • 1
  • Isabel R. Baumann
    • 1
  • Peter G. Waser
    • 1
  1. 1.Pharmakologisches Institut der Universität ZürichZürichSwitzerland

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