Abstract
DNA polymorphism patterns linked to the βA-globin gene were analyzed in healthy Japanese using four different restriction endonucleases. The chromosomes with the βA-globin gene were mapped through an evaluation of the presence of seven different restriction sites (HincII 5′ to ε; HindIII in Gγ and Aγ; HincII in, and 3′ to, ψβ1; AvaII in β; Bam-HI 3′ to β). Among 36 chromosomes analyzed, 20 chromosomes had a haplotype of [+−−−−−+]. Among 55 individuals examined, 7 possessed a homozygous haplotye of [+−−−−−+]. All Japanese with the AγT-globin gene had a subhaplotype of [−++−+] 5′ to the δ-globin gene. Their major haplotypes were [−++−+−+] and [−++−++−]. It was expected that the presence of the AγT-globin gene in Japanese may be deduced from subhaplotypes 5′ to the δ-globin gene.
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Shimizu, K. Characteristics of βA chromosome haplotypes in Japanese. Biochem Genet 25, 197–203 (1987). https://doi.org/10.1007/BF00499313
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DOI: https://doi.org/10.1007/BF00499313