Advertisement

Histochemistry

, Volume 48, Issue 4, pp 307–313 | Cite as

Paraganglia in the urogenital tract of man

  • A. Hervonen
  • A. Vaalasti
  • T. Vaalasti
  • M. Partanen
  • L. Kanerva
Article

Summary

According to the earlier concept, the paraganglia of man are believed to degenerate during the first postnatal years after their dominance during the fetal period. Clinical case reports on persisting paraganglia led us to extensive exploration of surgical material obtained from urological and gynecological surgery. The formaldehyde induced fluorescence (FIF) was used for tracing the catecholamine containing tissues. The fluorescence intensities were recorded with a Lietz MPV 2 microspectrophotometer.

Solitary, small paraganglia were found in all patients studied. They were expecially frequent in the walls of the urinary bladder and in the connective tissue surrounding the urogenital organs. The intensity of the fluorescence was comparable to pharmacological standard of 10−2 M noradrenaline and at the same level as the FIF of human fetal paraganglia. All cells of the paraganglionic clusters exhibited FIF and no signs of degeneration could be observed.

It is suggested that the paraganglia of man do not degenerate postnatally but persist as a remarcable catecholamine reservoir, which might be of physiological importance.

Keywords

Public Health Formaldehyde Fluorescence Intensity Connective Tissue Noradrenaline 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Brundin, T.: Studies on the preaortal paraganglia or newborn rabbits. Acta physiol. scand. 70, Suppl. 290 (1966)Google Scholar
  2. Burnstock, G., Costa, M.: Adrenergic neurons. Their organization function and development in the peripheral nervous system. London: Chapman & Hall (1975)Google Scholar
  3. Coupland, R.E.: The natural history of the chromaffin cell, London: Longman's 1965Google Scholar
  4. Doctor, V.M., Phadke, A.G., Sirsat, M.V.: Pheochromocytoma of the urinary bladder. Brit. J. Urol. 44, 351–353 (1972)Google Scholar
  5. Elfvin, L.-C.: A new granule-containing nerve cell in the interferior mesenteric ganglion of the rabbit. J. Ultrastruct. Res. 22, 37–41 (1968)Google Scholar
  6. Eränkö, O.: The practical histochemical of catecholamines by formaldehyde-induced fluorescence. J. roy. micr. Soc. 87, 259–276 (1967)Google Scholar
  7. Eränkö, O., Härkönen, M.: Monoamine containing small cells in the superior cervical ganglion of the rat and an organ composed of them. Acta physiol. scand. 63, 511–512 (1965)Google Scholar
  8. Fuselier, H.: Paraganglioma of the bladder: Report of a case. J. Urol. (Baltimore) 113, 42–44 (1975)Google Scholar
  9. Hervonen, A.: Development of catecholamine-storing cells in the human fetal paraganglia and adrenal medulla. Acta physiol. scand. Suppl. 368, 1 (1971)Google Scholar
  10. Hervonen, A., Korkala, O.: Histochemically demonstrable monoamines of human fetal carotid body. Experientia (Basel) 28, 449–450 (1972)Google Scholar
  11. Kanerva, L.: Development, histochemistry and connections of the paracervical (Frankenhäuser) ganglion of the rat uterus. Acta Inst. Anat. Univ. Helsinki, Suppl. 2 (1972)Google Scholar
  12. Kanerva, L., Hervonen, A.: SIF-cells, short adrenergic neurons and vacuolated nerve cells of the paracervical (Frankenhäuser) ganglion. In: Symposium on SIF-cells, Fogarty International Center, N.I.H., Government Printing Office Ed. O. Eränkö. 19–34 (1976)Google Scholar
  13. Kanerva, L., Hervonen, A., Hervonen, H.: Morphological characteristics of the ontogenesis of the mammalian peripheral adrenergic nervous system with special remarks on the human fetus. Med. Biol. 52, 144–158 (1974)Google Scholar
  14. Kohn, A.: Die Paraganglien Arch. mikr. Anat. 62, 263–365 (1903)Google Scholar
  15. Korkala, O., Hervonen, A.: Origin and development of the catecholamine-storing cells of the human fetal carotid body. Histochemie 37, 287–297 (1973)Google Scholar
  16. Kuo, T., Anderson, C.B., Rosai, J.: Normal paraganglia in the human gall-bladder. Arch. Path. 97, 46–47 (1974)Google Scholar
  17. Leestma, J.E., Pride, E.B.: Paraganglioma of the urinary bladder. Cancer (Philad.) 28, 1963–1968 (1971)Google Scholar
  18. Lempinen, M.: Extra-adrenal chromaffin tissue of the rat and the effect of cortical hormones on it. Acta physiol. scand. 62, Suppl. 231 (1964)Google Scholar
  19. Mascorro, J.A., Yates, R.D.: A review of abdominal paraganglia: Ultrastructure, mitotic cells, catecholamine release, innervation, light and dark cells, vascularity. In: Electron microscopic concepts of secretion. Ultrastructure of endocrinal and reproductive organs. (M. Hess, ed.). London-New York: John Wiley & Sons Inc. 1975Google Scholar
  20. Matthews, M.R., Raisman, G.: The ultrastructure and somatic efferent synapses of small granulecontaining cells in the superior cervical ganglion. J. Anat. (Lond.) 105, 255–282 (1969)Google Scholar
  21. Olson, J.R., Abell, M.R.: Nonfunctional, nonchromaffin, paragangliomas of the retroperitoneum. Cancer (Philad.) 23, 1358–1367 (1969)Google Scholar
  22. Scott, W.W., Eversole, S.L.: Pheochromocytoma of the urinary bladder. J. Urol. (Baltimore) 83, 656–662 (1960)Google Scholar
  23. Silver, J., Thomas, D., Young, R., Dowling, R.H.: Paeochomocytoma of the bladder. Proc. roy. Soc. Med. 64, 670–677 (1971)Google Scholar
  24. Zimmerman, I.J., Biron, R.E., MacMahon, H.E.: Pheochremocytoma of the urinary bladder. New Engl. J. Med. 249, 25–27 (1953)Google Scholar
  25. Zuckerkandl, E.: Über Nebenorgane des Sympaticus im Retroperitonealraum des Menschen. Anat. Anz. 15, 97–197 (1901)Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • A. Hervonen
    • 1
  • A. Vaalasti
    • 1
  • T. Vaalasti
    • 2
  • M. Partanen
    • 1
  • L. Kanerva
    • 3
  1. 1.Department of Biomedical SciencesUniversity of TampereTampere 52Finland
  2. 2.Department of UrologyTampere Central HospitalFinland
  3. 3.Department of Human AnatomyUniversity of CaliforniaDavisUSA

Personalised recommendations