Summary
The K+ release from the isolated perfused rat liver induced by phalloidin was strongly inhibited on raising the Mg2+ concentration of the perfusion medium from 0.5–40 mM while, in contrast, the phalloidin induced swelling of the organ and the vacuolisation of the liver tissue was not affected.
References
Agostini, B., Govindan, V. M., Hofmann, W., Wieland, Th.: Phalloidin-induced proliferation of actin filaments within rat hepatocytes. Z. Naturforsch. 30c, 793–795 (1975)
Frimmer, M., Gries, J., Hegner, D., Schnorr, B.: Untersuchungen zum Wirkungsmechanismus des Phalloidins. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 258, 197–214 (1967)
Govindan, V. M., Faulstich, H., Wieland, Th., Agostini, B., Hasselbach, W.: In-vitro effect of phalloidin on plasma membrane preparation from rat liver. Naturwissenschaften 59, 521–522 (1972)
Jahn, W.: dependence of the transmembrane water and ion shifts in the phalloidin poisoned rat liver on pH of the perfusion medium. Naunyn-Schmiedeberg's Arch. Pharmacol 286, 157–163 (1974)
Jahn, W., Lengsfeld, A.: Untersuchung der von den Perfusionsbedingungen abhängigen Aufnahme und Abgabe hochmolekularer Substanzen an der isolierten Rattenleber. Naunyn-Schmiedeberg's Arch. Pharmacol. 281, 241–256 (1974)
Lengsfeld, A., Jahn, W.: Endocytose an der isoliert perfundierten Rattenleber nach Phalloidinvergiftung. Cytobiologie 9, 391–400 (1974)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jahn, W. Differential effect of raised Mg2+ concentration on K+ ion movement and on swelling in the isolated perfused rat liver poisoned by phalloidin. Naunyn-Schmiedeberg's Arch. Pharmacol. 293, 197–198 (1976). https://doi.org/10.1007/BF00499229
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00499229