Summary
Cats with local tetanus were i.v. injected with dantrolene sodium. There is no effect of dantrolene sodium on the electromyogram in response to indirect stimulation of the non-poisoned muscle nor on the increased spontaneous activity of the poisoned muscle. The tension of the muscle, however, was strongly reduced.
References
Brooks, V. B., Curtis, D. R., Eccles, J. C.: The action of tetanus toxin on the inhibition of motoneurones. J. Physiol. (Lond.) 135, 655–672 (1957)
Ellis, K. O., Bryant, S. H.: Excitation-contraction uncoupling in skeletal muscle by dantrolene sodium. Naunyn-Schmiedeberg's Arch. Pharmacol. 274, 107–109 (1972)
Ellis, K. O., Castellion, A. W., Honkomp, L. J., Wessels, F. L., Carpenter, J. F., Halliday, R. P.: Dantrolene, a direct acting skeletal muscle relaxant. J. pharm. Sci. 62, 948–951 (1973)
Kano, M., Takano, K.: Gamma activity of rigid cat caused by tetanus toxin. Jap. J. Physiol. 19, 1–10 (1969)
Mayer, N., Mecomber, S. A., Herman, R.: Treatment of spasticyty with dantrolene sodium. Amer. J. Phys. Med. 52, 18–29 (1973)
Takano, K.: The effect of tetanus toxin on the extensor and flexor muslces of the hind leg of the cat. In: Animal, plant and microbial toxins (A. Ohsaka, K. Hayashi, and Y. Sawai, ed.), London: Plenum Publ. 1975
Takano, K., Henatsch, H.-D.: Tension-extension diagram of the tetanus-intoxicated muscle of the cat. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 421–436 (1973)
Takano, K., Kano, M.: Gamma-bias of the muscle poisoned by tetanus toxin. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 413–420 (1973)
Zorychta, E., Esplin, D. W., Capek, E. R., Lastowecka, A.: The actions of dantrolene on extrafusal and intrafusal striated muscle. Fed. Proc. 30, 669 (1971)
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Takano, K. Effect of dantrolene sodium upon the activity of the hind leg muscle of the cat with local tetanus. Naunyn-Schmiedeberg's Arch. Pharmacol. 293, 195–196 (1976). https://doi.org/10.1007/BF00499228
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DOI: https://doi.org/10.1007/BF00499228