Persistent enhancement of potassium-induced responses of the rat vas deferens by desipramine

  • D. Schneider
  • V. C. Swamy
Short Communication


The effect of desipramine on the cumulative dose-response curves of noradrenaline and potassium (K+) was examined on the isolated rat vas deferens. An exposure of 10 min to 10−7 M desipramine caused a leftward shift and an increase in the maximum response of cumulative dose-response curves of noradrenaline. Desipramine (10−7 M), in contact with the tissue for 10 min, enhanced responses to cumulative additions of K+ without causing a consistent change in threshold concentrations. Wash-out of desipramine resulted in a rapid loss of enhanced maximum response to noradrenaline while the maximum response to K+ did not show any decrease for up to 120 min after wash-out of drug. One possible explanation for the persistent enhancement of K+-induced responses may be that desipramine causes postjunctional changes which selectively influence contractile responses of this tissue to K+.

Key words

Desipramine Vas deferens Supersensitivity 


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • D. Schneider
    • 1
  • V. C. Swamy
    • 1
  1. 1.Department of Biochemical Pharmacology, School of PharmacyState University of New York at BuffaloBuffaloUSA

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