Summary
Chronic treatment of rats with chlorphentermine (44 mg/kg, per day, i.p. for 8 weeks) alters the lipid metabolism both of lung tissue and of alveolar macrophages (AM). Calculated for one lung three times more lipid could be extracted from lung tissue and ten times more from AM, compared with controls. The molar ratio lipids: chlorphentermine is 10∶1 in the lung tissue and 7∶1 in AM. It reflects the remarkable binding of this drug to lipids, which is supposed to be the reason for the reduced breakdown mainly of phospholipids.
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References
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Schmien, R., Seiler, KU. & Wassermann, O. Drug-induced phospholipidosis. Naunyn-Schmiedeberg's Arch. Pharmacol. 283, 331–334 (1974). https://doi.org/10.1007/BF00499192
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DOI: https://doi.org/10.1007/BF00499192