Abstract
Lysophospholipase (LPL) activity resulting from the intraperitoneal injection of dextran sulfate (DS) was studied in different mouse strains. AKR/J and BALB/cByJ mouse strains showed decreased LPL levels when a low molecular weight DS was injected but increased LPL activity when high molecular weight DS was injected intraperitoneally. C57BL/6 mice had increased LPL activity with low molecular weight DS but decreased LPL activity with high molecular weight DS. All three mouse strains showed increased peritoneal-cell changes when injected with DS of a molecular weight of 79,000.
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This work was supported in part by Grants 80-12-215 and 81-04-008 from the American Osteopathic Association.
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Laubach, H.E. Dextran sulfate-induced peritoneal lysophospholipase activity varies among mouse strains. Biochem Genet 23, 357–362 (1985). https://doi.org/10.1007/BF00499079
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DOI: https://doi.org/10.1007/BF00499079