Summary
Lindane (5×10−5M) causes a progressive and marked rise in MEPP frequency at the frog neuromuscular junction. Concentrations over a range of 5×10−6M to 5×10−4M were tested. The results suggest that it has two actions in promoting this effect. Its major effect is probably to cause an increase in Ca2+-permeability and a rise in Ca2+ entry. Its second, smaller effect, which persists in the absence of extracellular Ca2+, is probably also because of a rise in [Ca2+]i. The ways in which these effects might be produced and the significance of these findings for explaining the known pharmacological actions of lindane are discussed.
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Publicover, S.J., Duncan, C.J. The action of lindane in accelerating the spontaneous release of transmitter at the frog neuromuscular junction. Naunyn-Schmiedeberg's Arch. Pharmacol. 308, 179–182 (1979). https://doi.org/10.1007/BF00499062
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DOI: https://doi.org/10.1007/BF00499062