Summary
After male rats (100 g body weight) have completed 7 min of swimming at 15°C, their rectal temperature is decreased by 15°C. As expected, the increase of cAMP and the decrease of cGMP concentrations in adrenal medulla are delayed by the time period necessary for the body temperature to return to normal. Thus, taking into consideration the delaying effect of hypothermia, the swimming stress experiments are in agreement with the view that the enhancement of cyclic AMP/cGMP concentration ratios may function as the second messengers for the induction of tyrosine hydroxylase in adrenal medulla.
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References
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Guidotti, A., Costa, E. Association between increase in cyclic AMP and subsequent induction of tyrosine hydroxylase in rat adrenal medulla. Naunyn-Schmiedeberg's Arch. Pharmacol. 282, 217–221 (1974). https://doi.org/10.1007/BF00499036
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DOI: https://doi.org/10.1007/BF00499036