Summary
Schistosomal infection in mice caused an inhibition of the hepatic drug metabolizing enzyme activities. The magnitude of inhibition was not the same for all enzyme activities measured. MMAA and paraoxon metabolizing activities were only moderately affected.
Treatment of infected mice with schistosomicidal drugs produced a dramatic reversal of the inhibition in cases of MMAA and paraoxon metabolizing enzymes, the 2 activities mostly affected by schistosomal infection. On the other hand, the reversal of inhibition was not statistically significant in the other 2 enzyme activities.
Comparing the effectiveness of the different schistosomicidal drugs in reversing the inhibition produced by schistosomal infection, lucanthone HCl was found to be inferior to the other drugs used, namely, tartar emetic, stibophen and niridazole.
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Ghazal, A., Mahfouz, M., Makar, A.B. et al. Effect of schistosomal infection and of schistosomicidal drugs on the drug metabolizing enzymes of mouse liver. Naunyn-Schmiedeberg's Arch. Pharmacol. 282, 181–186 (1974). https://doi.org/10.1007/BF00499032
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DOI: https://doi.org/10.1007/BF00499032