Summary
3H-Chlorphentermine is selectively taken up by secreting tissues, the reticulo-endothelial and lymphatic system and other lipid-rich organs, like central nervous system, retina and lungs. Considerable amounts are still present at least 1 week after a single i.v. injection. The extensive binding of chlorphentermine in these lipid-or phospholipid-rich organs is probably due to strong complex formation between this drug and phospholipids. Comparison of this distribution pattern with that of other amphiphilic drugs of related structure (halogenated aralkylamines) suggests that a general mechanism might be involved in the observation reported.
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Seiler, K.U., Wassermann, O. Evidence for an unusual distribution of chlorphentermine in vivo. Naunyn-Schmiedeberg's Arch. Pharmacol. 282, 113–122 (1974). https://doi.org/10.1007/BF00499026
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DOI: https://doi.org/10.1007/BF00499026