Abstract
Acrylamide gel electrophoresis of mouse urine distinguishes two groups of pepsinogens, the fast-migrating group A and the slow-migrating group B. Inbred mouse strains fall into two categories with respect to group B pepsinogens, one expressing a single-banded and the other a double-banded phenotype. This variation is controlled by a single locus, urinary pepsinogen-2 or Upg-2, which has at least two alleles, Upg-2 s and Upg-2 d. Typing of recombinant inbred strains suggests that the location of the Upg-2 locus is on chromosome 1, in the vicinity of loci coding for other peptidases, namely, Pep-2 and Rnr, and of the Acf-1 locus.
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This work was supported in part by NIH Research Grant GM 18684 from the National Institute of General Medical Sciences. The Jackson Laboratory is fully accredited by The American Association for Accreditation of Laboratory Animal Care.
On leave from the Department of Comparative Anatomy, Jagellonian University, 30-060 Kraków, Poland.
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Szymura, J.M., Taylor, B.A. & Klein, J. Upg-2: A urinary pepsinogen variant located on chromosome 1 of the mouse. Biochem Genet 20, 1211–1219 (1982). https://doi.org/10.1007/BF00498944
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DOI: https://doi.org/10.1007/BF00498944