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Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 293, Issue 1, pp 105–108 | Cite as

Lack of correlation between changes in cyclic nucleotides and subsequent induction of tyrosine hydroxylase in rat adrenal medulla

  • U. Otten
  • H. Thoenen
Short Communication

Summary

Pretreatment of rats with dexamethasone (2.5 μmol/kg, a dose which blocks the release of ACTH from the pituitary gland) abolished the reserpine-mediated increase in cAMP and the increase in the cAMP/cGMP ratio in the adrenal medulla. In contrast, the reserpine-mediated induction of tyrosine hydroxylase (TH) remained unchanged. Hypophysectomy had a similar effect to dexamethasone treatment. Since changes in cAMP and changes in the cAMP/cGMP ratio are not indispensible prerequisites for the subsequent induction of TH, a causal relationship between the two phenomena seems to be excluded.

Key words

cAMP/cGMP ratio Tyrosine hydroxylase induction Reserpine Dexamethasone Hypophysectomy Adrenal medulla 

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • U. Otten
    • 1
  • H. Thoenen
    • 1
  1. 1.Department für PharmakologieBiozentrum der Universität BaselBaselSwitzerland

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