Summary
The effect of microelectrophoretically applied L-glutamate and acetylcholine on discharge activity of cortical neurones was studied in naive and in morphine-tolerant/dependent rats. The thresholds for increase in discharge activity elicited by these 2 putative neurotransmitters were 3 times lower in the tolerant/dependent rats than in the naive rats, indicating the development of supersensitivity.
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Satoh, M., Zieglgänsberger, W. & Herz, A. Supersensitivity of cortical neurones of the rat to acetylcholine and L-glutamate following chronic morphine treatment. Naunyn-Schmiedeberg's Arch. Pharmacol. 293, 101–103 (1976). https://doi.org/10.1007/BF00498877
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DOI: https://doi.org/10.1007/BF00498877