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Zur Verteilung und Hemmung esterolytischer Dermoproteinasen beim Menschen

Distribution and inhibition of human esterolytic dermoproteinases

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Summary

Homogenates of human skin contain extractible esterolytic proteinases, which show a similar substrate spectrum (ATYE, TAME) and inhibitors as the C′1-esterase in human blood. The activity of this proteinases in epidermis and epidermal proliferation was three fold higher than in cutis and skin tumors of the mesenchyma.

The esterolytic proteinases of the skin are inhibited by preincubation with human and guinea-pig sera containing the C′-1-inhibitor. The activity of these esterases in the skin and blood are obviously relevant for permeation processes in pathologic conditions.

Zusammenfassung

In Homogenaten der menschlichen Haut liegen extrahierbare esterolytische Proteinasen vor — in Epidermis und epidermalen Proliferationen (Basaliomen) mehr als in der Cutis — die ein ähnliches Substratspektrum (ATYE und TAME) besitzen wie die C′1-Esterase im menschlichen Blut. Diese Hautproteinasen werden durch Vorinkubation mit menschlichem und Meerschweinchen-Serum gehemmt. Die Aktivität derartiger Esterasen in der Haut und im Blut sind offenbar für Permeationsprozesse von besonderer Bedeutung.

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Literatur

  1. Carruthers, Ch.: Proteinases. In: Biochemistry of skin in health and disease. Springfield, Ill.: Ch. C. Thomas 1962.

    Google Scholar 

  2. Donaldson, V. H., and R. V. Evans: A biochemical abnormality in hereditary angioneurotic edema. Amer. J. Med. 35, 37–44 (1963).

    Google Scholar 

  3. Gross, R., u. G. Kroneberg: Neue Aspekte der Trasylol Therapie. Intern. Sympos. in Grosse Ledder 29. 3. 1965. Stuttgart: F. K. Schattauer 1966.

    Google Scholar 

  4. Lepow, I. H., and A. Ross: Studies on immune cellular injury. II. Functional role of C′1-esterase in immune cytotoxicity. J. exp. Med. 112, 1107 (1960).

    Google Scholar 

  5. Stüttgen, G.: Die normale und pathologische Physiologie der Haut. Stuttgart: G. Fischer 1965.

    Google Scholar 

  6. —, I. Gigli u. F. Herrmann: Pathophysiologie allergischer Dermatosen. XII. Congr. Intern. Dermat., München 1967. Berlin-Heidelberg-New York: Springer 1968.

    Google Scholar 

  7. Vogel, R., I. Trautschold u. E. Werle: Natürliche Proteinasen-Inhibitoren. Stuttgart: G. Thieme 1966.

    Google Scholar 

  8. Yamura, T., and F. E. Cormia: Studies on human skin protease. J. Derm. 37, 121–124 (1961).

    Google Scholar 

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Authors and Affiliations

  1. Hautklinik der Johann Wolfgang Goethe-Universität, Frankfurt am Main

    G. Stüttgen, Irma Gigli & P. Harth

  2. Univ.-Hautklinik der FU im Rudolf Virchow-Krankenhaus, Augustenburger Platz 1, 1000, Berlin 65

    G. Stüttgen

Authors
  1. G. Stüttgen
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  2. Irma Gigli
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  3. P. Harth
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Stüttgen, G., Gigli, I. & Harth, P. Zur Verteilung und Hemmung esterolytischer Dermoproteinasen beim Menschen. Arch. klin. exp. Derm. 235, 9–15 (1969). https://doi.org/10.1007/BF00498770

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  • DOI: https://doi.org/10.1007/BF00498770

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