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Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 292, Issue 2, pp 183–187 | Cite as

Conversion of angiotensin I in isolated perfused guinea-pig and rat lung

  • D. K. Meyer
  • R. Liebig
  • M. Abele
  • A. Jobke
  • G. Hertting
Article

Summary

Increasing concentrations of angiotensin I and different perfusion rates were used to study the conversion of angiotensin I in guinea-pig and rat lungs.

Even the highest concentration used (32.0 μM), which is a thousand times higher than that which occurs in vivo, was unable to saturate the converting system indicating the enormous capacity of this system. SQ 20881 proved to be a reversible inhibitor of the converting system. Its effect on the angiotensin I conversion was greater in guinea-pig lungs than in rat lungs (ID50 was 40.0 nM in guinea-pig lung and above 360.0 nM in rat lungs at a substrate concentration of 38.6 nM).

Key words

Angiotensin I conversion SQ 20881 Angiotensin II Guinea-pig lung Rat lung 

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • D. K. Meyer
    • 1
  • R. Liebig
    • 1
  • M. Abele
    • 1
  • A. Jobke
    • 1
  • G. Hertting
    • 1
  1. 1.Pharmakologisches Institut der UniversitätFreiburg im BreisgauFederal Republic of Germany

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