Summary
The actions of adenosine-5′-ethylcarboxamide (744–96), a long-acting adenosine analoge, on liver, portal and intestinal balances of glucose, lactate and pyruvate and on hepatic and portal blood flow were investigated in 6 chloralose-anaesthetized mongrel dogs. 744–96 led to an increase in portal and hepatic blood flow. Glucose release by the liver and glucose uptake by the non-hepatic splanchnic area (portal balance) were markedly increased by 744–96. Hepatic lactate and pyruvate balances were reversed from uptake to release by the adenosine analogue. The changes in glucose balances compare closely to the actions of glucagon, which is known to be released by 744–96. Apart from these possible glucagon-mediated actions, a direct action of the adenosine analogue must be assumed from the changes in lactate metabolism. The results of this study are indicative of a substratemobilising action of adenosine in addition to its wellknown vasodilatory action.
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Bergmeyer HU, Berndt E, Schmidt F, Stork H (1970) In: Bergmeyer HU (ed) Methoden der enzymatischen Analyse. Verlag Chemie, Weinheim, p 1163
Bücher T, Czok R, Lamprecht W, Latzko E (1970) In: Bergmeyer HU (ed) Methoden der enzymatischen Analyse. Verlag Chemie, Weinheim, p 253
Fischer U, Luyckx AS, Jutzi E, Hommel H, Lefebvre P (1978) Glucagon endogène et débit glucosé hépatique chez le chien anesthésié. Ann. d'Endocrinologie (Paris) 39:345–346
Henneman DH, Shoemaker WC (1961) Effect of glucagon and epinephrine on regional metabolism of glucose, pyruvate, lactate, and citrate in normal conscious dogs. Endocrinology 68:889–898
Hohorst H (1970) In: Bergmeyer HU (ed) Methoden der enzymatischen Analyse. Verlag Chemie, Weinheim, p 1425
McDougal, Borowitz JL (1972) The effect of Adenosine and cold storage on the response of the Guinea-Pig Ileum to Various Agonists. Arch Int Pharmacodyn 195:177–184
Raberger G, Schütz W, Kraupp O (1977) Coronary dilatory action of adenosine analogues: a comparative study. Arch Int Pharmacodyn 230:140–149
Raberger G, Schütz W, Kraupp O (1978) Cardiovascular and metabolic actions of an adenosine analogue (2′3′-o-methoxyethyliden-adenosine-5′-ethylcarboxamide) in the conscious dog. Arch Int Pharmacodyn 232:150–157
Scholtholt J, Lochner W, Renn H, Shiraishi T (1967) Die Wirkung von Noradrenalin, Adrenalin, Isoproterenol und Adenosin auf die Durchblutung der Leber und des Splanchnicusgebietes des Hundes. Pflügers Arch 293:129–154
Schultz ThA, Lewis StB, Westbie DK, Gerich JE, Rushakoff RJ, Wallin JD (1977) Glucose delivery — a clarification of its role in regulating glucose uptake in rat skeletal muscle. Life Sci 20:733–736
Schütz W, Raberger G, Kraupp O, Brugger G (1977) Effects of glucagon on liver metabolism in intact dogs. Res Exp Med 171:111–119
Schütz W, Raberger G, Kraupp O (1978a) Effects of a 2′, 3′, 5′-substituted adenosine derivative on systemic and coronary hemodynamics and on cardiac metabolism in the anesthetized dog. Arzneim Forsch/Drug Res 28:2079–2082
Schütz W, Raberger G, Kraupp O (1978b) Evidence for glucagonreleasing activity of vasoactive adenosine analogues in the conscious dog. Naunyn-Schmiedeberg's Arch Pharmacol 304:249–254
Stein HH, Somani P, Prasad RN (1975) Cardiovascular effects of nucleoside analogs. Ann NY Acad Sci 255:380–389
Turnheim K, Donath R, Weissel M, Kolassa N (1976) Myocardial glucose uptake and breakdown during adenosine-induced vasodilation. Pflügers Arch 365:197–202
Turnheim K, Plank B, Kolassa N (1978) Inhibition of adenosine uptake in human erythrocytes by adenosine-5′-carboxamides, xylosyladenine, dipyridamole, hexobendine, and p-nitrobenzylthioguanosine. Biochem Pharmacol 27:2191–2197
Van Nueten JM, Fontaine J, Helsen L, Janssen PAJ (1977) Inhibition by Purines of Peristaltic Activity in the Guinea-Pig Jleum. Arch Int Pharmacodyn 227:168–170
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Raberger, G., Benke, T. & Kraupp, O. The effects of adenosine-5′-ethylcarboxamide on liver blood flow and hepatic glucose, lactate and pyruvate balances in dogs. Naunyn-Schmiedeberg's Arch. Pharmacol. 314, 281–284 (1980). https://doi.org/10.1007/BF00498551
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DOI: https://doi.org/10.1007/BF00498551