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High affinity of carazolol for β-adrenoceptors coupled to the adenylyl cyclase in ventricular myocardium of kitten and xenopus laevis

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Summary

Catecholamine-induced stimulation of adenylyl cyclase in ventricular membranes of kitten and Xenopus laevis was antagonized competitively by carazolol. Apparent equilibrium constants ranging between 100–170 pM were estimated for the β-adrenoceptorcarazolol complex.

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Authors and Affiliations

  1. Department of Cell Biology, Bayior College of Medicine, 77030, Houston, Texas, USA

    T. H. Morris, L. Birnbaumer & A. J. Kaumann

  2. Physiologisches Institut, Lehrstuhl für Klinische Physiologie der Universität, Universitätsstrasse 1, D-4000, Düsseldorf, Federal Republic of Germany

    A. J. Kaumann

Authors
  1. T. H. Morris
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  2. L. Birnbaumer
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  3. A. J. Kaumann
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Morris, T.H., Birnbaumer, L. & Kaumann, A.J. High affinity of carazolol for β-adrenoceptors coupled to the adenylyl cyclase in ventricular myocardium of kitten and xenopus laevis . Naunyn-Schmiedeberg's Arch. Pharmacol. 303, 295–297 (1978). https://doi.org/10.1007/BF00498057

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  • DOI: https://doi.org/10.1007/BF00498057

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