Abstract
In the condensation of N-chloromethylisatin with indole and 2-methylindole in the presence of triethylamine, instead of the expected N-skatylisatins the products of their subsequent transformations with opening of the five-membered ring of isatin -o-(N-skatylamino)- and o[N-(2-methylskatyl)amino]benzoylcaproic acids —were isolated. In addition to the formation of these α-keto acids, under the indicated conditions one observes dimerization of N-chloromethylisatin and N-chloromethyl-5-methylisatin to give 2-(1-isatinylmethyloxy-3H-indolin-3-one and 2-(5-methyl-1-isatinylmethyloxy)-5-methyl-3H-indolin-3-one, respectively, i.e., dimers containing isatin rings in lactam and lactim forms. The structures of the compounds were confirmed by IR, PMR, and mass-spectral data.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 217–220, February, 1977.
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Zhungietu, G.I., Sinyavskaya, L.P. & Filipenko, T.Y. Reaction of 1-chloromethylisatin with indole. Chem Heterocycl Compd 13, 174–176 (1977). https://doi.org/10.1007/BF00497872
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DOI: https://doi.org/10.1007/BF00497872