Hypnoticlike effects of cannabidiol in the rat


The actions of cannabidiol (CBD), one of the cannabis constituents, were assessed on the sleep-wakefulness cycle of male Wistar rats.

During acute experiments, single doses of 20 mg/kg CBD decreased slow-wave sleep (SWS) latency. After 40 mg/kg SWS time was significantly increased while wakefulness was decreased. REM sleep was not significantly modified. Following the once-daily injections of 40 mg/kg CBD for a period of 15 days, tolerance developed to all the above-mentioned effects.

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  1. Karniol, I. G., Carlini, E. A.: Pharmacological interaction between cannabidiol and delta-9-tetrahydrocannabinol. Psychopharmacologia (Berl.) 33, 53–70 (1973)

    Google Scholar 

  2. King, C. D.: The pharmacology of rapid eye movement sleep. Adv. Pharmacol. Chemother. 9, 1–91 (1971)

    Google Scholar 

  3. Lidbrink, P.: The effect of lesions of ascending noradrenaline pathways on sleep and waking in the rat. Brain Res. 74, 19–40 (1974)

    Google Scholar 

  4. Michel, F., Klein, M., Jouvet, D., Valatx, J. L.: Etude polygraphique du sommeil chez le rat. C.R. Soc. Biol. (Paris) 155, 2289–2292 (1961)

    Google Scholar 

  5. Monti, J. M., Carlini, E. A.: Spontaneous behavior and sleep-wakefulness cycle in isolated and paired REM sleep deprived-marihuana treated rats. Pharmacol. Biochem. Behav. 3, 1025–1029 (1975)

    Google Scholar 

  6. Moreton, J. E., Davis, W. M.: Electroencephalographic study of the effects of tetrahydrocannabinols on sleep in the rat. Neuropharmacology 12, 897–907 (1973)

    Google Scholar 

  7. Steel, R. G. D., Torrie, J. H.: Principles and procedures of statistics. New York: McGraw-Hill 1960

    Google Scholar 

  8. Takahashi, R. N., Karniol, I. G.: Pharmacological interaction between cannabinol and delta-9-tetrahydrocannabinol. Psychopharmacologia (Berl.) 41, 277–284 (1975)

    Google Scholar 

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Monti, J.M. Hypnoticlike effects of cannabidiol in the rat. Psychopharmacology 55, 263–265 (1977). https://doi.org/10.1007/BF00497858

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Key words

  • Cannabidiol
  • Cannabis sativa
  • Slow-wave sleep
  • Wakefulness