Hypnoticlike effects of cannabidiol in the rat

Abstract

The actions of cannabidiol (CBD), one of the cannabis constituents, were assessed on the sleep-wakefulness cycle of male Wistar rats.

During acute experiments, single doses of 20 mg/kg CBD decreased slow-wave sleep (SWS) latency. After 40 mg/kg SWS time was significantly increased while wakefulness was decreased. REM sleep was not significantly modified. Following the once-daily injections of 40 mg/kg CBD for a period of 15 days, tolerance developed to all the above-mentioned effects.

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Monti, J.M. Hypnoticlike effects of cannabidiol in the rat. Psychopharmacology 55, 263–265 (1977). https://doi.org/10.1007/BF00497858

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Key words

  • Cannabidiol
  • Cannabis sativa
  • Slow-wave sleep
  • Wakefulness