Abstract
A craniocervical injury has been carried out in rats (with head free to move) so that they get through a whiplash without any coma.
Two days after the whiplash, comparable with a postcommotional syndrome, the acquisition of a labyrinth behavior is disturbed and, 7 days later, the retention is still disturbed.
This disturbance of retention is not observed when the acquisition is performed before the whiplash.
These data agree with the clinical observations, and we hypothesize a possible causal relation between the disturbance of learning behavior and the decrease of noradrenaline cerebral level induced by the whiplash.
Treatment with imipramine (1 mg/kg) after the whiplash is able to remove these behavioral and biochemical disturbances.
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Boismare, F., Le Poncin, M. & Lefrançois, J. Mémorisation et catécholamines centrales après un traumatisme cranio-cervical expérimental chez le rat: influence d'une administration d'imipramine. Psychopharmacology 55, 251–256 (1977). https://doi.org/10.1007/BF00497856
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DOI: https://doi.org/10.1007/BF00497856