Abstract
In unaneasthetized and unrestrained cats, muscarine and carbachol were injected into the cerebral ventricles. The kind of aggressive behaviour depended on the cholinomimetic drug and was classified as fear and an irritable kind of aggression. Muscarine induced the fear kind of aggression. The aggressive behaviour was usually preceded by attempts to escape and the attack was relevant to the situation. For the attack the presence of some threatening agent was needed. The aggression was accompanied by intense motor but less autonomic activation. On the other hand, carbachol induced an irritable kind of aggression and had the following characteristics: for the attack the presence of some threatening agent was not needed; the attack was not relevant to the situation; the aggression was not preceded by attempts to escape; and the aggressive behaviour was accompanied by intense motor and autonomic activation. It is concluded that cholinoceptive mechanisms are involved in the control of aggressive behaviour.
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References
Bard, P.: A diencephalic mechanism for expression of rage with special reference to the sympathetic nervous system. Am. J. Physiol. 84, 490–515 (1928)
Baxter, B. L.: Comparison of the behavioral effects of electrical or chemical stimulation applied at the same brain loci. Exp. Neurol. 19, 412–432 (1967)
Beleslin, D. B., Grbović, L., Radmanović, B. Ž.: The pharmacology of gross behavioural effects of cholinomimetic substances injected into the cerebral ventricles of unanaesthetized cats: evidence for central muscarinic mediation. Neuropharmacology 13, 1163–1169 (1974a)
Beleslin, D. B., Samardžić, R., Malobabić, Z. S.: An analysis of the gross behavioural changes induced by tetraethylammonium and a comparison with other substances affecting the autonomic and central nervous system after intraventricular injections to conscious cats. Neuropharmacology 13, 1171–1177 (1974b)
Beleslin, D., Samardžić, R.: Analyse pharmacologique de l'action de l'ésérine et de la néostigmine injectées dans le ventricule cérébral sur le comportement général du chat conscient. J. Pharmacol. (Paris) 7, 203–210 (1976)
Berntson, G. G., Leibowitz, S. F.: Biting attack in cats: evidence for central muscarinic mediation. Brain Res. 51, 366–370 (1973)
Connor, J. D., Rossi, G. V., Baker, W. W.: Analysis of the tremor induced by injection of cholinergic agents into the caudate nucleus. Int. J. Neuropharmacol. 5, 207–216 (1966)
Domino, E. F., Yamamoto, K., Dren, A. T.: Role of cholinergic mechanism in states of wakefulness and sleep. Prog. Brain Res. 28, 113–133 (1968)
Feldberg, W., Sherwood, S. L.: A permanent cannula for intraventricular injection in cats. J. Physiol. (Lond.) 120, 3–4P (1953)
Flynn, J. P., Vanegas, H., Foote, W., Edwards, S.: Neural mechanisms involved in a cat's attack on a rat. In: The neuronal control of behavior, R. E. Whalen, R. F. Thompson, M. Verzeano, and N. M. Weinberger, eds., pp. 135–173. New York: Academic Press 1970
George, R., Haslett, W. L., Jenden, D. J.: The production of tremor by cholinergic drugs: central sites of action. Int. J. Neuropharmacol. 5, 27–34 (1966)
Gunne, L.-M., Lewander, T.: Monoamines in brain and adrenal glands of cats after electrically induced defense reaction. Acta Physiol. Scand. 67, 405–410 (1966)
Karczmar, A. G.: Central actions of acetylcholine, cholinomimetics and related drugs. In: Biology of cholinergic function, A. M. Goldberg and I. Hanin, eds., pp. 395–449. New York: Raven Press 1976
Leslie, G. B.: Central stimulant properties of compounds with peripheral muscarinic properties. Nature 208, 1291–1293 (1965)
MacLean, P. D.: Chemical and electrical stimulation of hippocampus in unrestrained animals. A. M. A. Arch. Neurol. 78, 128–142 (1957)
Marley, E., Seller, T. J.: Effects of muscarine given into the brain of fowls. Br. J. Pharmacol. 44, 413–434 (1972)
McKenzie, G. M.: Apomorphine-induced aggression in the rat. Brain Res. 34, 323–331 (1971)
Myers, R. D.: Emotional and autonomic responses following hypothalamic chemical stimulation. Can. J. Psychol. 18, 6–14 (1964)
Moyer, K. E.: Kinds of aggression and their phyiological basis. Commun. Behav. Biol. [Part. A] 2, 65–87 (1968)
Reis, D. J.: The chemical coding of aggression in brain. In: Neurohumoral coding of brain function, R. D. Myers and R. R. Drucker-Colin, eds., pp. 125–150. New York: Plenum Press 1974
Reis, D. J., Miura, M., Weinbren, M., Gunne, L.-M.: Brain catecholamines: relation to defense reaction evoked by acute brainstem transection in cat. Science 156, 1768–1770 (1967)
Reis, D. J., Moorhead, D. T., Merlino, N.: Dopa-induced excitement in the cat. Arch. Neurol. 22, 31–39 (1970)
Riehl, J. L., Paul-David, J., Unna, K. R.: Comparison of the effects of arecoline and muscarine on the central nervous system. Int. J. Neuropharmacol. 1, 393–401 (1962)
Senault, B.: Comportement d'agressivité intraspécifique induit par l'apomorphine chez le rat. Psychopharmacologia (Berl.) 18, 271–287 (1970)
Stein, L., Seifter, J.: Muscarinic synapses in the hypothalamus. Am. J. Physiol. 202, 751–756 (1962)
Wasman, M., Flynn, J. P.: Direct attack elicited from hypothalamus. Arch. Neurol. 6, 60–67 (1962)
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Beleslin, D.B., Samardžić, R. Muscarine- and carbachol-induced aggressions: Fear and irritable kinds of aggressions. Psychopharmacology 55, 233–236 (1977). https://doi.org/10.1007/BF00497853
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DOI: https://doi.org/10.1007/BF00497853