Abstract
Five adult Macaca mulatta were studied during chronic administration (24 days) of S. 1694 (10 mg/kg, i.m.). This substance induced a significant increase of the first awakening (delaying sleep onset) and an enhancement of the duration of REM and stage 4 sleep. After withdrawal, the waking effect desappeared, but the increase in stage 4 sleep was maintained for one week and REM enhancement kept rising for 15 days. This observation of long-term action underlined the validity of drug experiments in chronic treatment: S. 1694 might set a new type of monoaminergic systems regulation.
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Balzamo, E., Santucci, V., Seri, B., Vuillon-Cacciuttolo, G., Bert, J.: Nonhuman Primates: Laboratory animals of choice for neurophysiologic studies of sleep. Lab. Anim. Sci. (in press 1977)
Bert, J., Balzamo, E.: Différenciation, des effects de la PCPA sur le sommeil de deux Primates appartenant au genre Papio. Electroencephalogr. Clin. Neurophysiol. 37, 161–166 (1974)
Bert, J., Saier, J., Tognetti, P., Toure, M. F.: Effet de la chlorimipramine sur l'activité de pointes «ponto-géniculo-occipitales» (PGO) du babouin Papio hamadryas. Psychopharmacology 51, 301–304 (1977)
Bert, J., Saier, J., Toure, M. F.: Comparaisons de l'effet de la chlomipramine sur le sommeil du singe et de l'Homme. Rev. Electroencephalogr. Neurophysiol. 6, 23–25 (1976)
DeVillard, R., Mouret, J.: Le somnambulisme: étude expérimentale et thérapeutique. Nouv. Presse Méd. 3, 44, 2660–2661 (1974)
Hill, S. V., Mendelson, W. B., Bernstein, D. A.: Cocaïe effects on sleep parameters in the rat. Psychopharmacology 51, 125–127 (1977)
Karacan, I., Thornby, J. I., Booth, G. H., Salis, P. J., Arch, A. M., Okawa, M., Williams, R. L.: Dose-response effects of natural and decaffeinated coffee and caffeïne on the sleep of normal young adult males. Sleep Research, vol. 3, M. H. Chase, W. C. Stern, and P. L., Walter, eds. p. 56. Los Angeles: B. I. S. University of California 1974
Lejeune, F., Passot, C., Poignant, J. C.: Effects d'un dérivé d'acide 7-amino heptanoïque (1964) sur les rythmes EEG. «Vth International Symposium on Medicinal Chemistry», Paris (1976) à paraître
Oswald, I.: Effects on sleep of amphetamine and its derivatives. In: Amphetamines and related compounds. Proceedings of the Mario Negri Institute for Pharmacological Research, Milan, Italy, E. Costa and S. Garattini, eds. pp. 865–871. New York: Raven Press 1970
Passouant, P., Cadilhac, J., Ribstein, M.: Les privations de sommeil avec mouvements oculaires par les anti-dépresseurs. Rev. Neurol. (Paris) 127, 173–192 (1972)
Petitjean, F., Jouvet, M.: Hypersomnie et augmentation de l'acide 5-hydroxy-indolacétique cérébral par lésion isthmique chez le chat. C. R. Soc. Biol. (Paris) 164, 2288–2293 (1970)
Samanin, R., Jori, A., Bernasconi, S., Morpurgo, E., Garattini, S.: Biochemical and pharmacological studies on amineptine (S-1694) and d-amphetamine in the rat. Pharmacy Pharmacol. in press 1977
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Balzamo, E., Vuillon-Cacciuttolo, G. Étude chez le singe rhésus des modifications du sommeil induites par le S. 1694 en administration prolongée. Psychopharmacology 55, 225–231 (1977). https://doi.org/10.1007/BF00497852
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DOI: https://doi.org/10.1007/BF00497852