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Changes in fixed-ratio performance and blood alcohol levels in monkeys

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Abstract

Three female Bonnet monkeys prepared with indwelling venous catheters were maintained on a fixed-ratio schedule of food reinforcement until response rates were stable. The animals were then intubated with alcohol (5.0 g/kg) 30 min prior to testing. Blood alcohol concentrations (BACs) were determined every 15 min throughout the 90-min session. Each alcohol intubation was separated by 3 days and on the second control day an isocaloric sucrose solution was intubated. The results show that the alcohol-induced response suppression gradually returns to baseline levels after 5 alcohol intubations, and the BACs were concomitantly decreased. The results indicate that the reversibility of alcohol induced behavioral impairments and changes in BACs develop within similar temporal intervals.

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Authors and Affiliations

  1. Psychophysiology Laboratory, Department of Psychiatry, Downstate Medical Center, State University of New York, 11203, Brooklyn, New York, USA

    Victor Denoble & Henri Begleiter

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  1. Victor Denoble
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  2. Henri Begleiter
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Denoble, V., Begleiter, H. Changes in fixed-ratio performance and blood alcohol levels in monkeys. Psychopharmacology 55, 213–216 (1977). https://doi.org/10.1007/BF00497850

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  • DOI: https://doi.org/10.1007/BF00497850

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