Summary
The site of action of naloxone to induce jumping in morphine tolerant/dependent rats appears to be dissociated from structures where apomorphine initiates its action to reinduce jumping in previously withdrawn animals. These findings suggest that dopaminergic pathways do not directly affect the neuronal circuit involved in withdrawal jumping behavior, but instead exert a facilitatory influence on neurons that become supersensitive during the state of withdrawal. Thus, an increased response to apomorphine during naloxone-precipitated opiate withdrawal does not necessarily imply a specific supersensitivity of the dopaminergic system.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bläsig, J., Gramsch, C., Laschka, E., Herz, A.: The role of dopamine in withdrawal jumping in morphine dependent rats. Arzneim.-Forsch. (Drug Res.) 26, 1004–1006 (1976)
Bläsig, J., Herz, A., Reinhold, K., Zieglgänsberger, S.: Development of physical dependence on morphine in respect to time and dosages and quantification of the precipitated withdrawal syndrome in rats. Psychopharmacologia (Berl.) 33, 19–38 (1973)
Collier, H. O. J.: A general theory of the genesis of drug dependence by induction of receptors. Nature 205, 181–182 (1965)
Fry, J. P., Zieglgänsberger, W., Herz, A.: Tachyphyllaxis to enkephalin-tolerance and dependence at the single neurone level? In: Iontophoresis and transmitter mechanisms in the mammalian central nervous system (Ryall and Kelly, eds.). Amsterdam: Elsevier/North-Holland Biomedical Press 1978
Herz, A., Schulz, R.: Changes in neuronal sensitivity during addictive processes. In: The basis of addiction (J. Fishman, ed.), pp. 375–394. Berlin: Dahlem Konferenzen 1978
Herz, A., Teschemacher, Hj., Albus, K., Zieglgänsberger, S.: Morphine abstinence syndrome in rabbits precipitated by injection of morphine antagonists into the ventricular system and restricted parts of it. Psychopharmacologia (Berl.) 26, 219–235 (1972)
Jaffe, J. H., Sharpless, S. K.: Pharmacological denervation supersensitivity in the central nervous system: a theory of physical dependence. Proc. Ass. Res. nerv. ment. Dis. 46, 226–246 (1968)
Lal, L.: Narcotic dependence, narcotic action and dopamine receptors. Life Sci. 17, 483–496 (1975)
Laschka, E., Herz, A.: Sites of action of morphine involved in the development of physical dependence in rats. Psychopharmacology 53, 33–37 (1977)
Laschka, E., Teschemacher, Hj., Mehraein, P., Herz, A.: Sites of action of morphine involved in the development of physical dependence in rats. Psychopharmacologia (Berl.) 46, 141–147 (1976)
North, R. A., Karras, P. J.: Opiate tolerance and dependence induced in vitro in single myenteric neurones. Nature 272, 73–75 (1978)
Schulz, R., Herz, A.: Aspects of opiate dependence in the myenteric plexus of the guinea-pig. Life Sci. 19, 1117–1128 (1976)
Schulz, R., Herz, A.: Naloxone-precipitated withdrawal reveals sensitization to neurotransmitters in morphine tolerant/dependent rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 299, 95–99 (1977)
Wei, E., Sigel, S. S. R., Loh, H. H., Way, E. L.: Central sites of naloxone-precipitated shaking in the anesthetized, morphinedependent rat. J. Pharmacol. exp. Ther. 195, 480–487 (1975)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schulz, R., Bläsig, J., Laschka, E. et al. Site of naloxone-precipitated opiate withdrawal dissociates from that at which apomorphine reinitiates this phenomenon. Naunyn-Schmiedeberg's Arch. Pharmacol. 305, 1–4 (1978). https://doi.org/10.1007/BF00496998
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00496998