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Erythrocyte organic phosphates in the anemia of renal failure in childhood

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Abstract

Erythrocyte 2,3-diphosphoglycerate (2,3-DPG) and adenosinetriphosphate (ATP) levels were determined in 43 children with chronic renal failure on conservative treatment (CT), and 12 children on regular hemodialysis (HD) immediately before and after a HD session. The results were compared to non-anemic and anemic controls. In spite of anemia, erythrocyte 2,3-DPG in renal failure was similar to non-anemic controls at normal blood pH, but rose during dialysis as a result of alkalosis. In contrast, ATP levels were high already at a normal blood pH. 2,3-DPG correlated with packed cell volume (PCV) in children with renal failure but at lower concentrations compared to controls. Both organic phosphates in the erythrocytes showed a significant correlation with blood pH. The poor increase of 2,3-DPG, in combination with elevated ATP levels, suggests uremia-induced inhibition of 2,3-DPG synthesis.

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Authors and Affiliations

  1. Department of Pediatrics, University of Heidelberg, Im Neuenheimer Feld 150, D-6900, Heidelberg, Federal Republic of Germany

    D. E. Müller-Wiefel, K. Schärer, W. Fischer & D. Michalk

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  1. D. E. Müller-Wiefel
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  2. K. Schärer
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  3. W. Fischer
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  4. D. Michalk
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Dedicated to Prof. Dr. H. Bickel on the occasion of his 60th birthday

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Müller-Wiefel, D.E., Schärer, K., Fischer, W. et al. Erythrocyte organic phosphates in the anemia of renal failure in childhood. Eur J Pediatr 128, 103–111 (1978). https://doi.org/10.1007/BF00496995

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  • DOI: https://doi.org/10.1007/BF00496995

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