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European Journal of Pediatrics

, Volume 147, Issue 4, pp 381–384 | Cite as

Haemorheologic and fibrinolytic evaluation in obese children and adolescents

  • E. Cacciari
  • A. Balsamo
  • G. Palareti
  • A. Cassio
  • R. Argento
  • M. Poggi
  • P. Tassoni
  • A. Cicognani
  • M. Tacconi
  • M. G. Pascucci
  • S. Coccheri
Original Investigations

Abstract

The haemorheologic condition was evaluated in 43 obese children and 35 controls. In 18 of the obese children and in 21 controls the euglobulin lysis time (ELT) was also studied. Blood viscosity at 94.5 and at 0.204 s-1 shear rates, plasma viscosity, fibrinogen and erythrocyte filtration time were significantly higher in obese than in control children. No significant differences were observed in haematocrit levels. Triglycerides, non-esterified fatty acids (NEFA), pre-β-lipoprotein and insulin rates were all significantly higher in obese than in control children. There were no significant differences in glycaemia and in haemoglobin A1 values. ELT, both basal and after stimulation with 1-deamino-8-d-arginine-vasopressin (DDAVP), was significantly higher in the obese than in control children. The haemorheologic disturbances together with alterations of the haemostatic balance and fibrinolysis may be an important risk factor for the development of vascular changes at paediatric age.

Key words

Obese children Haemorheology Pibrinolysis Risk factors 

Abbreviations

Htc

haematocrit

BV

blood viscosity

BV94

blood viscosity at 94.5 s-1 shear rates

BV0.2

blood viscosity

PV

plasma viscosity

RV

relative viscosity

EFT

erythrocyte filtration time test

ELT

euglobulin lysis time

NEFA

non-esterified fatty acids

HbA1

glycosilated haemoglobin

DDAVP

1-deamino-8-d-arginine-vasopressin

HDL

high density lipoprotein

MCV

mean corpuscular volume

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • E. Cacciari
    • 1
  • A. Balsamo
    • 1
  • G. Palareti
    • 2
  • A. Cassio
    • 1
  • R. Argento
    • 1
  • M. Poggi
    • 2
  • P. Tassoni
    • 1
  • A. Cicognani
    • 1
  • M. Tacconi
    • 1
  • M. G. Pascucci
    • 1
  • S. Coccheri
    • 2
  1. 1.Department of Paediatrics, 2nd Paediatric ClinicUniversity of BolognaBolognaItaly
  2. 2.Department of Angiology and Blood CoagulationUniversity HospitalBolognaItaly

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