Ultrastructural features of extramammary Paget's disease

  • R. Caputo
  • A. Califano


In the epidermis of a case of Paget's disease of the vulva two atypical cell variants (type I cells or clear cells and type II cells or dark cells) have been shown, which have the characteristic fine structure of glandular cells. The same finding has been noticed in Paget's disease of the nipple.

The authors favor the hypothesis that these cells migrate from the deepseated glandular tissue into the vulvar epithelium.


Public Health Fine Structure Clear Cell Nipple Ultrastructural Feature 
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Die ultrastrukturelle Untersuchung eines Falles von Morbus Paget der Vulva ergab, wie beim Morbus Paget der Mamma, in der Epidermis das Vorhandensein von 2 abnormen Zellstämmen (Zellen vom Typ I, d. h. helle Zellen, und Zellen vom Typ II, d. h. dunkle Zellen), die die ultrastrukturellen Charakteristiken der Zellen vom Typ der Drüsenzellen aufweisen.

Die Verff. halten daher die Hypothese einer migratorischen Histogenese der Paget-Zellen vom tiefer gelegenen Drüsengewebe für wahrscheinlicher.


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Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • R. Caputo
    • 1
    • 2
  • A. Califano
    • 1
    • 2
  1. 1.Clinica Dermatologica dell'Università di MilanoMilanoItaly
  2. 2.Istituto di Farmacologia dell'Università di MilanoMilanoItaly

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