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Ultrastructural features of extramammary Paget's disease

  • R. Caputo
  • A. Califano
Article

Summary

In the epidermis of a case of Paget's disease of the vulva two atypical cell variants (type I cells or clear cells and type II cells or dark cells) have been shown, which have the characteristic fine structure of glandular cells. The same finding has been noticed in Paget's disease of the nipple.

The authors favor the hypothesis that these cells migrate from the deepseated glandular tissue into the vulvar epithelium.

Keywords

Public Health Fine Structure Clear Cell Nipple Ultrastructural Feature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Die ultrastrukturelle Untersuchung eines Falles von Morbus Paget der Vulva ergab, wie beim Morbus Paget der Mamma, in der Epidermis das Vorhandensein von 2 abnormen Zellstämmen (Zellen vom Typ I, d. h. helle Zellen, und Zellen vom Typ II, d. h. dunkle Zellen), die die ultrastrukturellen Charakteristiken der Zellen vom Typ der Drüsenzellen aufweisen.

Die Verff. halten daher die Hypothese einer migratorischen Histogenese der Paget-Zellen vom tiefer gelegenen Drüsengewebe für wahrscheinlicher.

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References

  1. 1.
    Beaulaton, J. A.: Modifications ultrastructurales des cellules sécrétrices de la glande prethoracique de vers à soie au cours des deux dernier âges larvaires. J. Cell Biol. 39, 501–525 (1968).Google Scholar
  2. 2.
    Califano, A., Caputo, R.: La microscopia elettronica nello studio delle precancerosi epiteliali cutanee. Minerva derm. 43, 568–616 (1969).Google Scholar
  3. 3.
    Caputo, R., Lombardi, L.: Quadri ultrastrutturali dell'epidermide umana normale. Atti Accad. med. lombarda 18, 72–77 (1963).Google Scholar
  4. 4.
    Ebner, H.: Zur Ultrastruktur des Morbus Paget mamillae. Z. Haut u. Geschl.-Kr. 44, 297–304 (1969).Google Scholar
  5. 5.
    Ellis, R.: Eccrine, sebaceous and apocrine glands from ultrastructure of normal and abnormal skin, Zelickson, A., pp. 132–162 (1967).Google Scholar
  6. 6.
    Hashimoto, K., Gross, B., Lever, W.: The ultrastructure of human embryo skin. II. The formation of intradermal portion of the eccrine sweat duct and the secretory segment during the first half of embryonic life. J. invest. Derm. 46, 513–529 (1966).Google Scholar
  7. 7.
    Ishibashi, Y., Jager, G., Klingmuller, G.: Elektronenmikroskopische Untersuchung eines extramammaren Morbus Paget. Arch. klin. Derm. 234, 293–314 (1969).Google Scholar
  8. 8.
    Millonig, G.: Further observations on a buffer for osmium solution. Proc. 5th Intern. Congr. of Electron Microscopy. Philadelphia, New York: Academic Press 1962.Google Scholar
  9. 9.
    Munger, B. L.: Cytology of apocrine sweat glands. Z. Zellforsch. 68, 837–852 (1965).Google Scholar
  10. 10.
    Novikoff, A., Essner, E., Quintara, N.: Golgi apparatus and lysosomes. Fed. Proc. 23, 1010–1016 (1964).Google Scholar
  11. 11.
    Ofuji, S., Takeda, T.: An electron microscopic observation of genital Paget's disease. Acta derm. (Kyoto) 60, 209–213 (1965).Google Scholar
  12. 12.
    Toker, C.: Further observations on Paget's disease of the nipple. J. nat. Cancer Inst. 38, 79–92 (1967).Google Scholar
  13. 13.
    Wood, R.: General cell structure from ultrastructure of normal and abnormal skin, Zelickson, A., pp. 30–53 (1967).Google Scholar

Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • R. Caputo
    • 1
    • 2
  • A. Califano
    • 1
    • 2
  1. 1.Clinica Dermatologica dell'Università di MilanoMilanoItaly
  2. 2.Istituto di Farmacologia dell'Università di MilanoMilanoItaly

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