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Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes

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Summary

Autoantibodies to the insulin receptor mimic the effects of insulin on glycogen synthase and phosphorylase. The interaction of antibodies with adipocyte cell surface insulin receptors seems sufficient to promote stable changes in the activities of these intracellular enzymes, suggesting that internalization or processing of insulin is not important in the generation of these biological responses.

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Authors and Affiliations

  1. Department of Pharmacology, University of Virginia School of Medicine, 22903, Charlottesville, Virginia

    Joseph Larner, C. Ronald Kahn & Jesse Roth

  2. Diabetes Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, 20014, Bethesda, Maryland

    Joseph Larner, C. Ronald Kahn & Jesse Roth

Authors
  1. John C. Lawrence Jr.
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  2. Joseph Larner
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  3. C. Ronald Kahn
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  4. Jesse Roth
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Lawrence, J.C., Larner, J., Kahn, C.R. et al. Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes. Mol Cell Biochem 22, 153–158 (1978). https://doi.org/10.1007/BF00496241

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