Summary
The pathogenesis of diabetic retinopathy and the theoretical foundations of different methods of its phototherapy are reviewed. One aim of the treatment may be seen in the destruction of comparatively large retinal areas of small functional value, preferably in the periphery. Another aim of equal importance is the obliteration of the pathological vessels themselves. The two methods may also be combined.
At present we do not know exactly which of the two principles should be preferred in a given case of diabetic retinopathy. It should also be kept in mind that these methods are not sharply differentiated from each other because strictly selective treatment is not possible with available equipment. Our own strategy and the apparatus used are described.
Zusammenfassung
Es wird einleitend auf die Pathogenese und die theoretischen Grundlagen der verschiedenen Methoden der Phototherapie der diabetischen Retinopathie eingegangen.
Während im Prinzip ein Behandlungsziel in der weitgehenden Zerstörung von Netzhaut erblickt werden kann, und zwar vorzugsweise peripherer Gesichtsfeldareale von geringerer funktioneller Wertigkeit, ist ein ebenso wichtiges Ziel die Zerstörung der Netzhautgefäße selbst. Die beiden Methoden können auch kombiniert werden.
Wir wissen zur Zeit noch zu wenig genau, welchem der beiden Behandlungsprinzipien bei einer definierten Form der diabetischen Retinopathie der Vorzug gegeben werden soll. Im übrigen unterscheiden sich die beiden Behandlungsmethoden nur graduell, da es mit den zur Zeit verfügbaren Apparaten nicht möglich ist, streng selektiv zu arbeiten. Die von uns angewandte Behandlungsstrategie und die verwendeten Apparate werden beschrieben.
Similar content being viewed by others
Literatur
Aiello, L. M., Beetham, W. P., Balodimos, M. C., Chazan, B. I., Bradley, R. F.: Ruby Laser photocoagulation in treatment of diabetic proliferating retinopathy: Preliminary report. Symposium on the Treatment of Diabetic Retinopathy. Public Health Service Publ. No 1890, p. 437–463 (1968).
Baum, J. L., Wise, G. N.: Experimental subretinal neovascularisation. Trans. Amer. ophthal. Soc. 63, 91–107 (1959).
Beetham, W. P., Aiello, L. M., Balodimos, M. C., Koncz, L.: Ruby Laser photocoagulation of early diabetic neovascular retinopathy. Arch. Ophthal. 83, 261–272 (1970).
Cleasby, G. W.: Photocoagulation therapy of diabetic retinopathy. Symposium on the Treatment of Diabetic Retinopathy. Public Health Service Publ. No 1890, p. 465–477 (1968).
Davis, M. D.: Natural course of diabetic retinopathy, in: Vascular complications of diabetes mellitus, p. 139–169. Saint Louis: C. V. Mosby Company 1967.
Dobree, J. H.: Light coagulation in proliferative diabetic retinopathy. Symposium on the Treatment of Diabetic Retinopathy. Public Health Service Publ. No 1890, p. 47a-484 (1968).
—: The treatment of proliferative diabetic retinopathy. The William Mackenzie Centenary Symposium on the Ocular Circulation in Health and Disease, p. 195–199. London: Henry Kimpton 1969.
—: Simple diabetic retinopathy. Brit. J. Ophthal. 54, 3–10 (1970).
—, Taylor, E.: Treatment of proliferative diabetic retinopathy by light coagulation. Trans. ophthal. Soc. 88, 313–329 (1968).
Duke-Elder, S., Dobree, J. H.: The formation of avascular connective-tissue bands in proliferative diabetic retinopathy. Bibl. ophthal. (Basel) No 76, 133–138 (1968).
Fankhauser, F.: Die Photocoagulation mit dem Rubin- und Argon-Ionenlaser. Symp. dtsch. Ophthal. Ges., p. 131–151. München: Bergmann 1971.
- Giger, H., Lotmar, W., Roulier, A.: Vergleichende Behandlung der diabetischen Retinopathie durch Photokoagulation mit dem Argon-Laser und der Xenon-Hochdrucklampe. III. Modellmäßige Abschätzung der zum photokoagulativen Verschluß retinaler Blutgefäße erforderlichen Energie. (In Vorbereitung).
—, Lotmar, W., Roulier, A.: Photocoagulation through the Goldmann contact glass. Part II. Arch. Ophthal. 79, 674–683 (1968).
— — —: Dosimetry in photocoagulation. Arch. Ophthal. 85, 610–663 (1971a).
— — —: Reduction of energy in photocoagulation with the Zeiss-Oberkochen apparatus. Part. I. Albrecht v. Graefes Arch. klin. exp. Ophthal. 182, 177–188 (1971b).
- - - Vergleichende Behandlung der diabetischen Retinopathie durch Photokoagulation mit dem Argon-Laser und der Xenon-Hochdrucklampe. II. Teil. Klinische Ergebnisse. Graefes Archiv (1972a) (im Druck).
Kohner, E. M.: Persönliche Mitteilung 1971.
—, Dollery, C. T., Shakib, M., Hendkind, P., Paterson, J. W., Oliveira, L. N. F. de, Bulpitt, C. J.: Experimental retinal branch vein occlusion. Amer. J. Ophthal. 69, 778–825 (1970).
Kuwabara T., Aiello, L.: Effect of the Ruby Laser on the monkey retina: An electron microscopic study. Symposium on the Treatment of Diabetic Retinopathy. Public Health Service Publ. No 1890, p. 665–671 (1968).
Larsen, H. W.: Photocoagulation in proliferative diabetic retinopathy: a preliminary report. Symposium on the Treatment of Diabetic Retinopathy. Public Health Service Publ. No 1890, p. 495–506 (1968).
L'Esperance, F. A., Jr.: The effect of Laser radiation on the retinal vasculature. Arch. Ophthal. 74, 752–759 (1965).
—: The treatment of ophthalmic vascular disease by argon laser photocoagulation. Trans. Amer. Acad. Ophthal. Otolaryng. 73, 1077–1096 (1969).
Little, H. L., Zweng, H. Ch., Peabody, R. R.: Argon Laser retinal photocoagulation. Trans. Amer. Acad. Ophthal. Otolaryng. 74, 85–97 (1970).
Lotmar, W., Fankhauser, F., Roulier, A.: Photocoagulation through the Goldmann contact glass, Part IV. Arch. Ophthal. 82, 314–319 (1969).
McMeel, J. W., Heuven, W. A. J. van: Photocoagulation as a treatment of diabetic retinopathy. Symposium on the Treatment of Diabetic Retinopathy. Public Health Service Publ. No 1890, p. 507–514 (1968).
Meyer-Schwickerath, G., Wessing, A.: Treatment of diabetic retinopathy with photocoagulation; fluorescein studies. Concilium Ophthal. Acta 21, 293–298 (1971).
Michaelson, I. C.: Retinal circulation in man and animals p. 168. Springfield, Ill.: Charles C. Thomas Publisher 1954.
Mortimer, C. B.: Photocoagulation of diabetic retinopathy. Symposium on the Treatment of Diabetic Retinopathy. Public Health Service Publ. No 1890, p. 515–521 (1968).
Noyori, K. S., Campell, Ch. J., Rittler, C., Koester, Ch. J.: The characteristics of experimental Laser coagulation of the retina. Arch. Ophthal. 72, 254–263 (1964).
Okun, E.: Summary of treatment techniques from papers on photocoagulation. Symposium on the Treatment of Diabetic Retinopathy. Public Health Service Publ. No 1890, p. 623–629 (1968).
- Boniuk, I., Johnston, G. P.: Argon Laser photocoagulation. Mod. Probl. Ophthal. (Basel) (1971) (im Druck).
—, Johnston, G. P.: Role of photocoagulation in the treatment of proliferative diabetic retinopathy: Continuation and follow-up Studies. Symposium on the Treatment of Diabetic Retinopathy. Public Health Service Publ. No 1890, p. 523–535 (1968).
Roulier, A.: Calculation of temperature increase in the eye produced by intense light. Bull. Math. Biophys. 32, 403–427 (1970).
Straatsma, B. R.: Summary of visual and anatomic results from papers on photocoagulation. Symposium on the Treatment of Diabetic Retinopathy. Public Health Service Publ. No 1890, p. 607–611 (1968).
Taylor, E.: Proliferative diabetic retinopathy. Brit. J. Ophthal. 54, 535–539 (1970).
Thornfeldt, P. R.: Photocoagulation for Retinitis proliferans. Symposium on the Treatment of Diabetic Retinopathy. Public Health Service Publ. No 1890, p. 555–557 (1968).
Welch, R. B.: The treatment of diabetic retinopathy. Symposium on the Treatment of Diabetic Retinopathy. Public Health Service Publ. No 1890, p. 563–568 (1968).
Wessing, A.: Behandlung der diabetischen Retinopathie mit Lichtkoagulation. In: Handbuch des Diabetes mellitus Bd. II, herausgeg. v. E. F. Pfeiffer, München: Lehmann 1970.
- Meyer-Schwickerath, G.: Fluorescein studies in cases of diabetic retinopathy treated with photocoagulation. Symposium international sur l'angiographie fluorescéinique, Albi 1969. Kongreßband herausgeg. von P. Amalric (in Vorbereitung).
— —, Meyer-Schwickerath, G.: Results of photocoagulation in diabetic retinopathy. Symposium on the Treatment of Diabetic Retinopathy. Public Health Service Publ. No 1890, p. 569–592 (1968).
Zweng, H. Ch.: Argon Laser photocoagulation in diabetic retinopathy. Mod. Probl. Ophthal. (Basel) (1971) (im Druck).
—, Little, H. L., Peabody, R.R.: Laser photocoagulation and retinal angiography. Saint Louis: C. V. Mosby Company 1970.
Author information
Authors and Affiliations
Additional information
This work has been supported by a Grant to the University of Bern, Number EY 00232 from the NINDB, National Institutes of Health, Bethesda, Maryland, U.S.A.
Rights and permissions
About this article
Cite this article
Fankhauser, F., Lotmar, W. & Roulier, A. Vergleichende Behandlung der diabetischen Retinopathie durch Photocoagulation mit dem Argon-Laser und der Xenon-Hochdrucklampe. Albrecht von Graefes Arch. Klin. Ophthalmol. 183, 334–347 (1972). https://doi.org/10.1007/BF00496160
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00496160