Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 328, Issue 1, pp 83–86 | Cite as

The effect of imipramine and desipramine on mixed function oxidase in rats

  • W. Daniel
  • J. Friebertschäuser
  • C. Steffen
Article

Summary

The effects of imipramine and desipramine on hepatic mixed function oxidase were measured in male Wistar rats. Both antidepressants increased hepatic cytochrome P-450 when given b.i.d. for 7 or 14 days. In vitro demethylation of imipramine was rather depressed than increased. 14CO2 exhalation from [N-methyl-14C] benzphetamine was increased by pretreatment with the antidepressants as well as with phenobarbital, but imipramine had no influence on the exhalation of the label from [6-methoxy-14C]-or [7-methoxy-14C]-scoparone.

No difference was observed between treatment with imipramine or desipramine. It is concluded that changes of the demethylation rate of imipramine are not responsible for its delayed elimination observed after chronic treatment (Daniel et al. 1981).

Key words

Imipramine Desipramine Cytochrome P-450 Drug metabolism 14CO2 breath test 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • W. Daniel
    • 2
  • J. Friebertschäuser
    • 1
  • C. Steffen
    • 1
  1. 1.Department of PharmacologyPhilipps-UniversityMarburgGermany
  2. 2.Department of Biochemistry, Institute of PharmacologyPolish Academy of SciencesKrakowPoland

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