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Autosomal dominant inheritance of hypercalciuria

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Abstract

We examined 37 first and second degree relatives of 10 children with hypercalciuria. In 2 families only the index patient was affected, while in 8 others one of the parents was hypercalciuric; in the total of 47 persons examined 23 cases of “idiopathic” hypercalciuria could be identified. None of the subjects was hypercalcemic. The pedigrees suggest autosomal dominant inheritance of the trait.

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References

  • Bulusu, A., Hodgkinson, A., Nordin, B. E. C., Peacock, M.: Urinary excretion of calcium and creatinine in relation to age and body weight in normal subjects and patients with renal calculus. Clin. Sci. 38, 601–612 (1970)

    Google Scholar 

  • Coe, F. L.: Treated and untreated recurrent calcium nephrolithiasis in patients with idiopathic hypercalciuria, hyperuricosuria, or no metabolic disorder. Ann. Intern. Med. 87, 404–410 (1977)

    Google Scholar 

  • Coe, F. L., Parks, J. H., Moore, E. S.: Familial idiopathic hypercalciuria. New Engl. J. Med. 300, 337–340 (1979)

    Google Scholar 

  • DeLuca, R., Guzzetta, F.: L'ipercalciuria idiopatica infantile. Pediatria. 73, 613–640 (1965)

    Google Scholar 

  • Ghazali, S., Barratt, T. M.: Urinary excretion of calcium and magnesium in children. Arch. Dis. Child 49, 97–101 (1974)

    Google Scholar 

  • Hodgkinson, A., Pyrah, L. N.: The urinary excretion of calcium and inorganic phosphate in 344 patients with calcium stones of renal origin. Brit. J. Surg. 46, 10–18 (1958)

    Google Scholar 

  • McKusick, V.: Mendelian inheritance in man. Catalogs of autosomal dominant, autosomal recessive, and X-linked phenotypes. 5th edition. Baltimore-London: Johns Hopkins Univ. Press 1978

    Google Scholar 

  • Méhes, K.: Epidemiology of inherited disorders of calcium/ phosphate metabolism (abstract). Pediat. Res. 10, 893 only (1976)

    Google Scholar 

  • Moore, E. S., Coe, F. L., McMann, B. J., Favus, M. J.: Idiopathic hypercalciuria in children: prevalence and metabolic characteristics. J. Pediat. 92, 906–910 (1978)

    Google Scholar 

  • Nordin, B. E. C.: Hypercalciuria. Clin. Sci. Molec. Med. 52, 1–9 (1977)

    Google Scholar 

  • Pak, C. Y. C., Ohata, M., Lawrence, E. C., Snyder, W.: The hypercalciurias. Causes, parathyroid functions,and diagnostic criteria. J. Clin. Invest. 54, 387–400 (1974)

    Google Scholar 

  • Paunier, L., Borgeaud, M., Wyss, M.: Urinary excretion of magnesium and calcium in normal children. Helvet. Paediat. Acta 25, 577–586 (1970)

    Google Scholar 

  • Robertson, W. G., Morgan, D. B.: The distribution of urinary calcium excretion in normal persons and stone formers. Clin. Chim. Acta. 37, 503–510 (1972)

    Google Scholar 

  • Rose, G. A., Harrison, A. R.: The incidence, investigation and treatment of idiopathic hypercalciuria. Brit. J. Urol. 46, 261–274 (1974)

    Google Scholar 

  • Sokol, Y., Winter, S. T., Boxer, J., Kana'aneh, H.: Urinary calcium excretion in schoolboys. Ethnic group differences. Israel J. Med. Sci. 14, 432–435 (1978)

    Google Scholar 

  • Szelid, Zs., Zámori, A.,Méhes, K.: Urinary calcium excretion in normal children (Hungarian). Orvosi Hetilap 120, 678–682 (1979)

    Google Scholar 

  • Widdowson, E. M., McCance, R.A.: Use of random specimens of urine to compare dietary intakes of African and British children. Arch. Dis. Childh.45, 547–552 (1970)

    Google Scholar 

  • Yendt, E. R., Cohanim, M.: Prevention of calcium stones with thiazides. Kidney Internat. 13, 397–409 (1978)

    Google Scholar 

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Dedicated to Prof. Dr. H.-R. Wiedemann on the occasion of his 65th birthday

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Méhes, K., Szelid, Z. Autosomal dominant inheritance of hypercalciuria. Eur J Pediatr 133, 239–242 (1980). https://doi.org/10.1007/BF00496083

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  • DOI: https://doi.org/10.1007/BF00496083

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