Abstract
Active uptake of serotonin by blood platelets of acute schizophrenic patients has been compared to that of a control group. Preliminary results presented in this article indicate that the uptake of the schizophrenic patients was about 40% lower than that of controls. Patients were followed over a period of 5 weeks with no significant change in uptake.
Similar content being viewed by others
References
Axelrod, J.: The enzymatic N-methylation of serotonin and other amines. J. Pharmacol. Exp. Ther. 138, 28–33 (1962)
Banerjee, S. P., Snyder, S. H.: methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines. Science 182, 74–75 (1972)
Garely, E., Gillin, J. C., Wyatt, R. J., Neff, N.: Elevated blood serotonin concentrations in unmedicated chronic schizophrenic patients: A preliminary study. Am. J. Psychiatry 132, 184–186 (1975)
Gillin, J. C., Kaplan, J., Stillman, R., Wyatt, R. J.: The psychedelic model of schizophrenia: The case of N-N-dimethyl tryptamine. Am. J. Psychiatry 133, 203–208 (1976)
Meltzer, H. Y., Stahl, S. M.: Platelets monoamine oxidaze activity and substrate preferences in schizophrenic patients. Res. Comm. Chem. Pathol. Pharmacol. 7, 419–431 (1974)
Morgan, M., Mandell, A. J.: Indole(ethyl)amine N-methyl-transferase in the brain. Science 165, 492–493 (1969)
Murphy, D. L., Wyatt, R. J.: Reduced MAO activity in blood platelets from schizophrenic patients. Nature 238, 225–226 (1972)
Saavedra, J. M., Axelrod, J.: Psychotominetic N-methylated tryptamines: Formation in brain in vivo and in vitro. Science 175, 1365–1366 (1972)
Saavedra, J. M., Coyle, J. T., Axelrod, J.: The distribution and properties of the nonspecific N-methyltransferase in brain. J. Neurochem 20, 743–752 (1973)
Schneider, K.: Primare and sekundare symptome bei schizophrenia. Fortschr. Neurol. Psychiatr. 25, 487 (1957)
Sneddon, J. M.: Blood platelets as a model for monoaminecontaining neurons. Prog. Neurobiol. 1, 151–198 (1973)
Snyder, S. H.: The copamine hypothesis of schizophrenia: Focus on the dopamine receptor. Am. J. Psychiatry 133, 197–202 (1976)
Wise, C. D., Stein, L.: Dopamine beta hydroxylase deficit in the brains of schizophrenic patients. Science 181, 344–347 (1973)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Modai, I., Rotman, A., Munitz, H. et al. Serotonin uptake by blood platelets of acute schizophrenic patients. Psychopharmacology 64, 193–195 (1979). https://doi.org/10.1007/BF00496061
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00496061