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Inhibition by loperamide of deoxycholic acid induced intestinal secretion

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Summary

The effect of loperamide on deoxycholic acid (DOC)-induced secretion was studied in ligated loops of the rat jejunum and colon in vivo. In controls loperamide slightly augmented fluid absorption. 3 mmol DOC caused net fluid secretion. Loperamide reduced this secretion in the colon and reversed it to absorption in the jejunum. Na-K-ATPase specific activity and cAMP levels were measured in the jejunum, and [14C]erythritol clearance as an index of mucosal permeability in the colon. In the jejunum this opiate analogue affected neither basal or DOC-depressed Na-K-ATPase, nor mucosal cAMP. In the colon it reduced a large increase of the erythritol clearance caused by DOC. It is suggested that loperamide interferes with DOC-induced intestinal secretion in part by lowering mucosal permeability.

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Authors and Affiliations

  1. Medizinische Klinik Innenstadt der Universität München, Ziemssenstrasse 1, D-8000, München 2, Federal Republic of Germany

    U. M. Farack & K. Loeschke

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  1. U. M. Farack
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  2. K. Loeschke
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Supported by the Deutsche Forschungsgemeinschaft (Lo 114/12-5)

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Farack, U.M., Loeschke, K. Inhibition by loperamide of deoxycholic acid induced intestinal secretion. Naunyn-Schmiedeberg's Arch. Pharmacol. 325, 286–289 (1984). https://doi.org/10.1007/BF00495957

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  • DOI: https://doi.org/10.1007/BF00495957

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