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Butyl hydroxy toluene antagonizes the gastric toxicity but not the pharmacological activity of acetylsalicylic acid in rats

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Summary

Butyl hydroxy toluene reduced gastric erosion due to acetylsalicylic acid in the rat, but not the antiinflammatory, anti-pyretic and analgesic activity. By itself, BHT exhibited activity only in the test on analgesia.

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Author notes

  1. A. A. van Kolfschoten

    Present address: Department of Toxicology, Duphar B. V., P. O. Box 2, NL-1380 AA, Weesp, The Netherlands

Authors and Affiliations

  1. Laboratory for Pharmacology, National Institute of Public Health, P.O.Box 1, NL-3720 BA, Bilthoven, The Netherlands

    A. A. van Kolfschoten & F. Hagelen

  2. Department of Toxicology, Duphar B. V., P. O. Box 2, NL-1380 AA, Weesp, The Netherlands

    J. van Noordwijk

Authors
  1. A. A. van Kolfschoten
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  2. F. Hagelen
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  3. J. van Noordwijk
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van Kolfschoten, A.A., Hagelen, F. & van Noordwijk, J. Butyl hydroxy toluene antagonizes the gastric toxicity but not the pharmacological activity of acetylsalicylic acid in rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 325, 283–285 (1984). https://doi.org/10.1007/BF00495956

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  • DOI: https://doi.org/10.1007/BF00495956

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