Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 325, Issue 3, pp 193–197 | Cite as

Facilitation of the Bezold-Jarisch reflex by central stimulation of alpha2 adrenoceptors in dogs

  • D. W. G. Harron
  • W. Kobinger
Article

Summary

The Bezold-Jarisch reflex characterized by hypotension and bradycardia was elicited in anaesthetized artificially respired dogs (pretreated with a beta-adrenoceptor antagonist) using capsaicin 10 μg/kg (i.v.). Intracisternal administration of the highly selective “clonidine-like” alpha2 adrenoceptor agonists B-HT 920 (10 μg/kg) or B-HT 933 (30 μg/kg) significantly facilitated this reflex bradycardia. The involvement of central alpha2-adrenoceptors is suggested as intracisternal administration of the alpha2 adrenoceptor blocking drugs yohimbine (50 μg/kg) and piperoxan (50 μg/kg) antagonized this facilitation. B-HT 920 also facilitated the vagally mediated baroreceptor reflex to the hypertensive effect of intravenous noradrenaline (3 μg/kg). Although the Bezold-Jarisch reflex and the baroreceptor reflex have different afferent pathways, both reflexes may either converge into a common pathway or have separate neuronal chains within the medulla; however, this study indicates that both have a similar central modulatory system stimulated by alpha2 adrenoceptors.

Key words

Bezold-Jarisch reflex Baroreceptor reflex Alpha agonists CNS-Facilitation Alpha antagonists 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • D. W. G. Harron
    • 1
  • W. Kobinger
    • 1
  1. 1.Pharmakologische AbteilungErnst-Boehringer-Institut für ArzneimittelforschungWienAustria

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